PDB entry 2y66

View 2y66 on RCSB PDB site
Description: new 5-benzylidenethiazolidine-4-one inhibitors of bacterial murd ligase: design, synthesis, crystal structures, and biological evaluation
Deposited on 2011-01-20, released 2011-10-19
The last revision was dated 2011-11-02, with a file datestamp of 2011-10-28.
Experiment type: XRAY
Resolution: 1.49 Å
R-factor: 0.19003
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: udp-n-acetylmuramoylalanine--d-glutamate ligase
    Species: Escherichia coli [TaxId:83333]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14900 (Start-437)
      • expression tag (438-439)
  • Heterogens: N04, DMS, SO4, SO3, CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2y66A (A:)
madyqgknvviiglgltglscvdfflargvtprvmdtrmtppgldklpeaverhtgslnd
ewlmaadlivaspgialahpslsaaadagieivgdielfcreaqapivaitgsngkstvt
tlvgemakaagvnvgvggniglpalmllddecelyvlelssfqlettsslqavaatilnv
tedhmdrypfglqqyraaklriyenakvcvvnaddaltmpirgadercvsfgvnmgdyhl
nhqqgetwlrvkgekvlnvkemklsgqhnytnalaalaladaaglprasslkalttftgl
phrfevvlehngvrwindskatnvgsteaalnglhvdgtlhlllggdgksadfsplaryl
ngdnvrlycfgrdgaqlaalrpevaeqtetmeqamrllaprvqpgdmvllspacasldqf
knfeqrgnefarlakelgshhhhhh

    Sequence, based on observed residues (ATOM records):
    >2y66A (A:)
adyqgknvviiglgltglscvdfflargvtprvmdtrmtppgldklpeaverhtgslnde
wlmaadlivaspgialahpslsaaadagieivgdielfcreaqapivaitgsngkstvtt
lvgemakaagvnvgvggniglpalmllddecelyvlelssfqlettsslqavaatilnvt
edhmdrypfglqqyraaklriyenakvcvvnaddaltmpircvsfgvnmgdyhlnhqqge
twlrvkgekvlnvkemklsgqhnytnalaalaladaaglprasslkalttftglphrfev
vlehngvrwindskatnvgsteaalnglhvdgtlhlllggdgksadfsplarylngdnvr
lycfgrdgaqlaalrpevaeqtetmeqamrllaprvqpgdmvllspacasldqfknfeqr
gnefarlakelgsh