PDB entry 2y42

View 2y42 on RCSB PDB site
Description: Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with NADH and Mn
Class: oxidoreductase
Keywords: oxidoreductase, leub, leucine biosynthesis
Deposited on 2011-01-04, released 2011-01-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-04-18, with a file datestamp of 2012-04-13.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.17951
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (2)
      • expression tag (348)
    Domains in SCOPe 2.08: d2y42a1, d2y42a2, d2y42a3
  • Chain 'B':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (348-352)
    Domains in SCOPe 2.08: d2y42b1, d2y42b2
  • Chain 'C':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (2)
      • expression tag (348-353)
    Domains in SCOPe 2.08: d2y42c1, d2y42c2, d2y42c3
  • Chain 'D':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:274]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (2)
      • expression tag (348-356)
    Domains in SCOPe 2.08: d2y42d1, d2y42d2, d2y42d3
  • Heterogens: BCN, NAD, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2y42A (A:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2y42A (A:)
smkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrk
gveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplk
eeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkh
vvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnif
gdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammle
hafglvelarkvedavakalletpppdlggsagteaftatvlrhlaa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2y42B (B:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2y42B (B:)
mkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrkg
veeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplke
eiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkhv
vsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnifg
dilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammleh
afglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaale

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2y42C (C:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2y42C (C:)
smkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrk
gveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplk
eeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkh
vvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnif
gdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammle
hafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaaleh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2y42D (D:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2y42D (D:)
smkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrk
gveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplk
eeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkh
vvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnif
gdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammle
hafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhh