PDB entry 2y3a

View 2y3a on RCSB PDB site
Description: crystal structure of p110beta in complex with icsh2 of p85beta and the drug gdc-0941
Deposited on 2010-12-20, released 2011-03-16
The last revision was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8BTI9
      • conflict (150)
  • Chain 'B':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit beta
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GD9

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2y3aA (A:)
msyyhhhhhhdydipttenlyfqgamgsmppamadnldiwavdsqiasdgaisvdfllpt
giyiqlevpreatisyikqmlwkqvhnypmfnllmdidsymfacvnqtavyeeledetrr
lcdvrpflpvlklvtrscdpaekldskigvligkglhefdalkdpevnefrrkmrkfsea
kiqslvglswidwlkhtyppehepsvlenledklyggklvvavhfensqdvfsfqvspnl
npikinelaiqkrltirgkedeaspcdyvlqvsgrveyvfgdhpliqfqyirncvmnrtl
phfilvecckikkmyeqemiaieaainrnssnlplplppkktrvishiwdnnnpfqitlv
kgnklnteetvkvhvraglfhgtellcktvvsseisgkndhiwneqlefdinicdlprma
rlcfavyavldkvktkkstktinpskyqtirkagkvhypvawvntmvfdfkgqlrsgdvi
lhswssfpdeleemlnpmgtvqtnpyaenatalhitfpenkkqpcyyppfdkiiekaael
asgdsanvssrggkkflavlkeildrdplsqlcenemdliwtlrqdcrenfpqslpklll
sikwnkledvaqlqallqiwpklpprealelldfnypdqyvreyavgclrqmsdeelsqy
llqlvqvlkyepfldcalsrflleraldnrrigqflfwhlrsevhtpavsvqfgvileay
crgsvghmkvlskqvealnklktlnsliklnavklsrakgkeamhtclkqsayrealsdl
qsplnpcvilselyvekckymdskmkplwlvyssrafgedsvgvifkngddlrqdmltlq
mlrlmdllwkeagldlrmlpygclatgdrsglievvstsetiadiqlnssnvaataafnk
dallnwlkeynsgddldraieeftlscagycvasyvlgigdrhsdnimvkktgqlfhidf
ghilgnfkskfgikrervpfiltydfihviqqgktgntekfgrfrqccedaylilrrhgn
lfitlfalmltaglpeltsvkdiqylkdslalgkseeealkqfkqkfdealreswttkvn
wmahtvrkdyrs

    Sequence, based on observed residues (ATOM records):
    >2y3aA (A:)
avdsqiasdgaisvdfllptgiyiqlevpreatisyikqmlwkqvhnypmfnllmdidsy
mfacvnqtavyeeledetrrlcdvrpflpvlklvtrscdpaekldskigvligkglhefd
alkdpevnefrrkmrkfseakiqslvglswidwlkhtyppehepsvlenledklyggklv
vavhfensqdvfsfqvspnlnpikinelaiqkrltaspcdyvlqvsgrveyvfgdhpliq
fqyirncvmnrtlphfilvecckikkmyeqemiaieaaiiwdnnnpfqitlvkgnklnte
etvkvhvraglfhgtellcktvvsseisgkndhiwneqlefdinicdlprmarlcfavya
vvawvntmvfdfkgqlrsgdvilhswssfpdeleemlnpmgtvqtnpyaenatalhitfp
enkkqpcyyppfdkiiekaaelagkkflavlkeildrdplsqlcenemdliwtlrqdcre
nfpqslpklllsikwnkledvaqlqallqiwpklpprealelldfnypdqyvreyavgcl
rqmsdeelsqyllqlvqvlkyepfldcalsrflleraldnrrigqflfwhlrsevhtpav
svqfgvileaycrgsvghmkvlskqvealnklktlnsliklnavklsrakgkeamhtclk
qsayrealsdlqsplnpcvilselyvekckymdskmkplwlvyssrafgedsvgvifkng
ddlrqdmltlqmlrlmdllwkeagldlrmlpygclatgdrsglievvstsetiadiqlns
snvaataafnkdallnwlkeynsgddldraieeftlscagycvasyvlgigdrhsdnimv
kktgqlfhidfghilgnfkskfgikrervpfiltydfihviqqgktgntekfgrfrqcce
daylilrrhgnlfitlfalmltaglpeltsvkdiqylkdslalgkseeealkqfkqkfde
alreswttkvnwmaht

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2y3aB (B:)
msqqdqvvkedsveavgaqlkvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafne
tikifeeqgqtqekcskeylerfrregnekemqrillnserlksriaeihesrtkleqdl
raqasdnreidkrmnslkpdlmqlrkirdqylvwltqkgarqrkinewlgiknetedqys
lmededalphheertwyvgkinrtqaeemlsgkrdgtfliressqrgcyacsvvvdgdtk
hcviyrtatgfgfaepynlygslkelvlhyqhaslvqhndaltvtlahpvrapgpgppsa
ar

    Sequence, based on observed residues (ATOM records):
    >2y3aB (B:)
kvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafnetikifeeqgqtqekcskeyl
gnekemqrillnserlksriaeihesrtkleqdlraqasdnreidkrmnslkpdlmqlrk
irdqylvwllphheertwyvgkinrtqaeemlsgkrdgtfliressqrgcyacsvvvdgd
tkhcviyrtatgfgfaepynlygslkelvlhyqhaslvqhndaltvtlahpvrapg