PDB entry 2xyn

View 2xyn on RCSB PDB site
Description: human abl2 in complex with aurora kinase inhibitor vx-680
Class: transferase
Keywords: cell adhesion, structural genomics consortium, sgc, transferase
Deposited on 2010-11-18, released 2010-12-01
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-04-20, with a file datestamp of 2011-04-15.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: 0.24782
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ABL2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2xyna_
  • Chain 'B':
    Compound: Tyrosine-protein kinase ABL2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2xynb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase ABL2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2xync_
  • Heterogens: NA, VX6, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xynA (A:)
mghhhhhhssgvdlgtenlyfqsmdkwemertditmkhklgggqygevyvgvwkkysltv
avktlkedtmeveeflkeaavmkeikhpnlvqllgvctleppfyivteympygnlldylr
ecnreevtavvllymatqissameylekknfihrdlaarnclvgenhvvkvadfglsrlm
tgdtytahagakfpikwtapeslayntfsiksdvwafgvllweiatygmspypgidlsqv
ydllekgyrmeqpegcppkvyelmracwkwspadrpsfaethqafetmfhds

    Sequence, based on observed residues (ATOM records): (download) 
    >2xynA (A:)
kwemertditmkhklgggqygevyvgvwkkysltvavktldtmeveeflkeaavmkeikh
pnlvqllgvctleppfyivteympygnlldylrecnreevtavvllymatqissameyle
kknfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapeslaynt
fsiksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelmrac
wkwspadrpsfaethqafetmfhd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xynB (B:)
mghhhhhhssgvdlgtenlyfqsmdkwemertditmkhklgggqygevyvgvwkkysltv
avktlkedtmeveeflkeaavmkeikhpnlvqllgvctleppfyivteympygnlldylr
ecnreevtavvllymatqissameylekknfihrdlaarnclvgenhvvkvadfglsrlm
tgdtytahagakfpikwtapeslayntfsiksdvwafgvllweiatygmspypgidlsqv
ydllekgyrmeqpegcppkvyelmracwkwspadrpsfaethqafetmfhds

    Sequence, based on observed residues (ATOM records): (download) 
    >2xynB (B:)
kwemertditmkhklgggqygevyvgvwkkysltvavktldtmeveeflkeaavmkeikh
pnlvqllgvctleppfyivteympygnlldylrecnreevtavvllymatqissameyle
kknfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapeslaynt
fsiksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelmrac
wkwspadrpsfaethqafetmfhd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2xynC (C:)
mghhhhhhssgvdlgtenlyfqsmdkwemertditmkhklgggqygevyvgvwkkysltv
avktlkedtmeveeflkeaavmkeikhpnlvqllgvctleppfyivteympygnlldylr
ecnreevtavvllymatqissameylekknfihrdlaarnclvgenhvvkvadfglsrlm
tgdtytahagakfpikwtapeslayntfsiksdvwafgvllweiatygmspypgidlsqv
ydllekgyrmeqpegcppkvyelmracwkwspadrpsfaethqafetmfhds

    Sequence, based on observed residues (ATOM records): (download) 
    >2xynC (C:)
wemertditmkhklgggqygevyvgvwkkysltvavktlktmeveeflkeaavmkeikhp
nlvqllgvctleppfyivteympygnlldylrecnreevtavvllymatqissameylek
knfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapeslayntf
siksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelmracw
kwspadrpsfaethqafetmfh