PDB entry 2xyj

View 2xyj on RCSB PDB site
Description: Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy
Class: transcription
Keywords: transcription
Deposited on 2010-11-18, released 2011-02-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor delta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2xyja_
  • Chain 'B':
    Compound: Peroxisome proliferator-activated receptor delta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2xyjb_
  • Heterogens: WLM, 1PE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xyjA (A:)
mkkghhhhhhggsqynpqvadlkafskhiynaylknfnmtkkkarsiltgkashtapfvi
hdietlwqaekglvwkqlvnglppykeisvhvfyrcqcttvetvreltefaksipsfssl
flndqvtllkygvheaifamlasivnkdgllvangsgfvtreflrslrkpfsdiiepkfe
favkfnalelddsdlalfiaaiilcgdrpglmnvprveaiqdtilralefhlqanhpdaq
ylfpkllqkmadlrqlvtehaqmmqrikktetetslhpllqeiykdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >2xyjA (A:)
adlkafskhiynaylknfnmtkkkarsiltgshtapfvihdietlwqaekglvwkqglpp
ykeisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamlasi
vnkdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaaiil
cgdrpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaqmm
qrikktetetslhpllqeiykdm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xyjB (B:)
mkkghhhhhhggsqynpqvadlkafskhiynaylknfnmtkkkarsiltgkashtapfvi
hdietlwqaekglvwkqlvnglppykeisvhvfyrcqcttvetvreltefaksipsfssl
flndqvtllkygvheaifamlasivnkdgllvangsgfvtreflrslrkpfsdiiepkfe
favkfnalelddsdlalfiaaiilcgdrpglmnvprveaiqdtilralefhlqanhpdaq
ylfpkllqkmadlrqlvtehaqmmqrikktetetslhpllqeiykdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >2xyjB (B:)
adlkafskhiynaylknfnmtkkkarsiltgtapfvihdietlwqaekglvwglppykei
svhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamlasivnkd
gllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaaiilcgdr
pglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaqmmqrik
ktetetslhpllqeiykdm