PDB entry 2xx7

View 2xx7 on RCSB PDB site
Description: crystal structure of 1-(4-(1-pyrrolidinylcarbonyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1h-indazole in complex with the ligand binding domain of the rat glua2 receptor and glutamate at 2.2a resolution.
Class: transport protein
Keywords: transport protein, ampa receptor ligand-binding core, ion channel
Deposited on 2010-11-09, released 2011-04-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-09-28, with a file datestamp of 2011-09-23.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.16802
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19491 (148-290)
      • expression tag (29-30)
      • linker (146-147)
      • engineered mutation (270)
    Domains in SCOPe 2.08: d2xx7a1, d2xx7a2
  • Chain 'B':
    Compound: Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19491 (148-290)
      • expression tag (29-30)
      • linker (146-147)
      • engineered mutation (270)
    Domains in SCOPe 2.08: d2xx7b1, d2xx7b2
  • Chain 'C':
    Compound: Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19491 (148-290)
      • linker (146-147)
      • engineered mutation (270)
    Domains in SCOPe 2.08: d2xx7c_
  • Heterogens: GLU, 1ND, SO4, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xx7A (A:)
mgsshhhhhhssglvprgshmgsgndtsrganktvvvttilespyvmmkknhemlegner
yegycvdlaaeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiaplt
itlvreevidfskpfmslgisimikkgtpiesaedlskqteiaygtldsgstkeffrrsk
iavfdkmwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrkpcdtmkv
ggnldskgygiatpkgsslgnavnlavlklseqglldklknkwwydkgecg

    Sequence, based on observed residues (ATOM records): (download) 
    >2xx7A (A:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xx7B (B:)
mgsshhhhhhssglvprgshmgsgndtsrganktvvvttilespyvmmkknhemlegner
yegycvdlaaeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiaplt
itlvreevidfskpfmslgisimikkgtpiesaedlskqteiaygtldsgstkeffrrsk
iavfdkmwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrkpcdtmkv
ggnldskgygiatpkgsslgnavnlavlklseqglldklknkwwydkgecg

    Sequence, based on observed residues (ATOM records): (download) 
    >2xx7B (B:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2xx7C (C:)
mgsshhhhhhssglvprgshmgsgndtsrganktvvvttilespyvmmkknhemlegner
yegycvdlaaeiakhcgfkykltivgdgkygardadtkiwngmvgelvygkadiaiaplt
itlvreevidfskpfmslgisimikkgtpiesaedlskqteiaygtldsgstkeffrrsk
iavfdkmwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrkpcdtmkv
ggnldskgygiatpkgsslgnavnlavlklseqglldklknkwwydkgecg

    Sequence, based on observed residues (ATOM records): (download) 
    >2xx7C (C:)
nktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkyg
ardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtpie
saedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvr
kskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlkls
eqglldklknkwwydkgecg