PDB entry 2xwt
View 2xwt on RCSB PDB site
Description: crystal structure of the tsh receptor in complex with a blocking type tshr autoantibody
Class: signaling protein/immune system
Keywords: signaling protein-immune system complex, gpcr, graves' disease, autoimmunity, receptor-autoantibody complex
Deposited on
2010-11-05, released
2011-03-09
The last revision prior to the SCOPe 2.03 freeze date was dated
2011-03-09, with a file datestamp of
2011-03-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.17943
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: thyroid blocking human autoantibody k1-70 heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: thyroid blocking human autoantibody k1-70 light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d2xwtb1, d2xwtb2 - Chain 'C':
Compound: thyrotropin receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d2xwtc_ - Heterogens: NAG, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2xwtB (B:)
qsvltqppsvsaapgqkvtiscsgsssdigsnyvswyqqfpgtapklliydnnkrpsaip
drfsgsksgtsatlgitglqtgdeadyycgtwdsrlgiavfgggtqltvlgqpkaapsvt
lfppsseelqankatlvclvsdfypgavtvawkadgspvkvgvettkpskqsnnkyaass
ylsltpeqwkshrsyscrvthegstvektvapte
Sequence, based on observed residues (ATOM records): (download)
>2xwtB (B:)
svltqppsvsaapgqkvtiscsgsssdigsnyvswyqqfpgtapklliydnnkrpsaipd
rfsgsksgtsatlgitglqtgdeadyycgtwdsrlgiavfgggtqltvlgqpkaapsvtl
fppsseelqankatlvclvsdfypgavtvawkadgspvkvgvettkpskqsnnkyaassy
lsltpeqwkshrsyscrvthegstvektvapte
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2xwtC (C:)
mgcssppcechqeedfrvtckdiqripslppstqtlkliethlrtipshafsnlpnisri
yvsidvtlqqleshsfynlskvthieirntrnltyidpdalkelpllkflgifntglkmf
pdltkvystdiffileitdnpymtsipvnafqglcnetltlklynngftsvqgyafngtk
ldavylnknkyltvidkdafggvysgpslldvsqtsvtalpskglehlkeliarntwtl
Sequence, based on observed residues (ATOM records): (download)
>2xwtC (C:)
cssppcechqeedfrvtckdiqripslppstqtlkliethlrtipshafsnlpnisriyv
sidvtlqqleshsfynlskvthieirntrnltyidpdalkelpllkflgifntglkmfpd
ltkvystdiffileitdnpymtsipvnafqglcnetltlklynngftsvqgyafngtkld
avylnknkyltvidkdafggvysgpslldvsqtsvtalpskglehlkeliarnt