PDB entry 2xwt

View 2xwt on RCSB PDB site
Description: crystal structure of the tsh receptor in complex with a blocking type tshr autoantibody
Class: signaling protein/immune system
Keywords: signaling protein-immune system complex, gpcr, graves' disease, autoimmunity, receptor-autoantibody complex
Deposited on 2010-11-05, released 2011-03-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thyroid blocking human autoantibody k1-70 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2XWT (0-220)
    Domains in SCOPe 2.08: d2xwta_
  • Chain 'B':
    Compound: thyroid blocking human autoantibody k1-70 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2XWT (Start-213)
    Domains in SCOPe 2.08: d2xwtb1, d2xwtb2
  • Chain 'C':
    Compound: thyrotropin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2xwtc_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xwtA (A:)
evqlvqsgaevkkpgqslkisckasgysltdnwigwvrqkpgkglewmgiiypgdsdtry
spsfqgqvtisadksintaylqwsslkasdtaiyycvgldwnynplrywgpgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

    Sequence, based on observed residues (ATOM records): (download) 
    >2xwtA (A:)
evqlvqsgaevkkpgqslkisckasgysltdnwigwvrqkpgkglewmgiiypgdsdtry
spsfqgqvtisadksintaylqwsslkasdtaiyycvgldwnynplrywgpgtlvtvssa
stkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xwtB (B:)
qsvltqppsvsaapgqkvtiscsgsssdigsnyvswyqqfpgtapklliydnnkrpsaip
drfsgsksgtsatlgitglqtgdeadyycgtwdsrlgiavfgggtqltvlgqpkaapsvt
lfppsseelqankatlvclvsdfypgavtvawkadgspvkvgvettkpskqsnnkyaass
ylsltpeqwkshrsyscrvthegstvektvapte

    Sequence, based on observed residues (ATOM records): (download) 
    >2xwtB (B:)
svltqppsvsaapgqkvtiscsgsssdigsnyvswyqqfpgtapklliydnnkrpsaipd
rfsgsksgtsatlgitglqtgdeadyycgtwdsrlgiavfgggtqltvlgqpkaapsvtl
fppsseelqankatlvclvsdfypgavtvawkadgspvkvgvettkpskqsnnkyaassy
lsltpeqwkshrsyscrvthegstvektvapte

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2xwtC (C:)
mgcssppcechqeedfrvtckdiqripslppstqtlkliethlrtipshafsnlpnisri
yvsidvtlqqleshsfynlskvthieirntrnltyidpdalkelpllkflgifntglkmf
pdltkvystdiffileitdnpymtsipvnafqglcnetltlklynngftsvqgyafngtk
ldavylnknkyltvidkdafggvysgpslldvsqtsvtalpskglehlkeliarntwtl

    Sequence, based on observed residues (ATOM records): (download) 
    >2xwtC (C:)
cssppcechqeedfrvtckdiqripslppstqtlkliethlrtipshafsnlpnisriyv
sidvtlqqleshsfynlskvthieirntrnltyidpdalkelpllkflgifntglkmfpd
ltkvystdiffileitdnpymtsipvnafqglcnetltlklynngftsvqgyafngtkld
avylnknkyltvidkdafggvysgpslldvsqtsvtalpskglehlkeliarnt