PDB entry 2xwe

View 2xwe on RCSB PDB site
Description: x-ray structure of acid-beta-glucosidase with 5n,6s-(n'-(n-octyl) imino)-6-thionojirimycin in the active site
Deposited on 2010-11-02, released 2011-09-14
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (2-498)
      • expression tag (1)
      • variant (496)
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (2-498)
      • expression tag (1)
      • variant (496)
  • Heterogens: PO4, K, AMF, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2xweA (A:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records):
    >2xweA (A:)
farpcipksfgyssvvcvcnatycdsfdpppalgtfsryestrsgrrmelsmgpiqanht
gtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirv
pmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwts
ptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagll
sgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpea
akyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgm
qyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlg
hfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfle
tispgysihtylwhrq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2xweB (B:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records):
    >2xweB (B:)
farpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqan
htgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigynii
rvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspw
tsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsag
llsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdp
eaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdr
gmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyh
lghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgf
letispgysihtylwhrq