PDB entry 2xwb

View 2xwb on RCSB PDB site
Description: crystal structure of complement c3b in complex with factors b and d
Deposited on 2010-11-01, released 2011-01-12
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3.49 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: complement c3b beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: complement c3b alpha' chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (0-911)
      • see remark 999 (261)
  • Chain 'C':
    Compound: complement c3b beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: complement c3b alpha' chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (0-911)
      • see remark 999 (261)
  • Chain 'F':
    Compound: complement factor b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00751 (0-729)
      • engineered mutation (244)
      • engineered mutation (250)
      • expression tag (730-731)
  • Chain 'H':
    Compound: complement factor b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00751 (0-729)
      • engineered mutation (244)
      • engineered mutation (250)
      • expression tag (730-731)
  • Chain 'I':
    Compound: complement factor d
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00746 (0-227)
      • engineered mutation (182)
  • Chain 'J':
    Compound: complement factor d
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00746 (0-227)
      • engineered mutation (182)
  • Heterogens: MG, NAG, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2xwbA (A:)
spmysiitpnilrleseetmvleahdaqgdvpvtvtvhdfpgkklvlssektvltpatnh
mgnvtftipanrefksekgrnkfvtvqatfgtqvvekvvlvslqsgylfiqtdktiytpg
stvlyriftvnhkllpvgrtvmvnienpegipvkqdslssqnqlgvlplswdipelvnmg
qwkirayyenspqqvfstefevkeyvlpsfeviveptekfyyiynekglevtitarflyg
kkvegtafvifgiqdgeqrislpeslkripiedgsgevvlsrkvlldgvqnpraedlvgk
slyvsatvilhsgsdmvqaersgipivtspyqihftktpkyfkpgmpfdlmvfvtnpdgs
payrvpvavqgedtvqsltqgdgvaklsinthpsqkplsitvrtkkqelseaeqatrtmq
alpystvgnsnnylhlsvlrtelrpgetlnvnfllrmdraheakiryytylimnkgrllk
agrqvrepgqdlvvlplsittdfipsfrlvayytligasgqrevvadsvwvdvkdscvgs
lvvksgqsedrqpvpgqqmtlkiegdhgarvvlvavdkgvfvlnkknkltqskiwdvvek
adigctpgsgkdyagvfsdagltftsssgqqtaqraelqcpq

    Sequence, based on observed residues (ATOM records):
    >2xwbA (A:)
spmysiitpnilrleseetmvleahdaqgdvpvtvtvhdfpgkklvlssektvltpatnh
mgnvtftipanrefkkgrnkfvtvqatfgtqvvekvvlvslqsgylfiqtdktiytpgst
vlyriftvnhkllpvgrtvmvnienpegipvkqdslssqnqlgvlplswdipelvnmgqw
kirayyenspqqvfstefevkeyvlpsfeviveptekfyyiynekglevtitarflygkk
vegtafvifgiqdgeqrislpeslkripiedgsgevvlsrkvlldgvqnpraedlvgksl
yvsatvilhsgsdmvqaersgipivtspyqihftktpkyfkpgmpfdlmvfvtnpdgspa
yrvpvavqgedtvqsltqgdgvaklsinthpsqkplsitvrtkkqelseaeqatrtmqal
pystvgnsnnylhlsvlrtelrpgetlnvnfllrmdraheakiryytylimnkgrllkag
rqvrepgqdlvvlplsittdfipsfrlvayytligasgqrevvadsvwvdvkdscvgslv
vksgqsedrqpvpgqqmtlkiegdhgarvvlvavdkgvfvlnkknkltqskiwdvvekad
igctpgsgkdyagvfsdagltftsssgqqtaqraelqcpq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2xwbB (B:)
dediiaeenivsrsefpeswlwnvedlkeppkngistklmniflkdsittweilavsmsd
kkgicvadpfevtvmqdffidlrlpysvvrneqveiravlynyrqnqelkvrvellhnpa
fcslattkrrhqqtvtippksslsvpyvivplktglqevevkaavyhhfisdgvrkslkv
vpegirmnktvavrtldperlgregvqkedippadlsdqvpdtesetrillqgtpvaqmt
edavdaerlkhlivtpsgcgeenmigmtptviavhyldeteqwekfglekrqgalelikk
gytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilek
qkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitk
agdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynve
atsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdapdhqe
lnldvslqlpsrsskithrihwesasllrseetkenegftvtaegkgqgtlsvvtmyhak
akdqltcnkfdlkvtikpapetekrpqdakntmileictryrgdqdatmsildismmtgf
apdtddlkqlangvdryiskyeldkafsdrntliiyldkvshseddclafkvhqyfnvel
iqpgavkvyayynleesctrfyhpekedgklnklcrdelcrcaeencfiqksddkvtlee
rldkacepgvdyvyktrlvkvqlsndfdeyimaieqtiksgsdevqvgqqrtfispikcr
ealkleekkhylmwglssdfwgekpnlsyiigkdtwvehwpeedecqdeenqkqcqdlga
ftesmvvfgcpn

    Sequence, based on observed residues (ATOM records):
    >2xwbB (B:)
dediiaeenivsrsefpeswlwnvedlkeppkngistklmniflkdsittweilavsmsd
kkgicvadpfevtvmqdffidlrlpysvvrneqveiravlynyrqnqelkvrvellhnpa
fcslattkrrhqqtvtippksslsvpyvivplktglqevevkaavyhhfisdgvrkslkv
vpegirmnktvavrtldperlgregvqkedippadlsdqvpdtesetrillqgtpvaqmt
edavdaerlkhlivtpsgcgeenmigmtptviavhyldeteqwekfglekrqgalelikk
gytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilek
qkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitk
agdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynve
atsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdapdhqe
lnldvslqlpsrsskithrihwesasllrseetkenegftvtaegkgqgtlsvvtmyhak
akdqltcnkfdlkvtikpapkntmileictryrgdqdatmsildismmtgfapdtddlkq
langvdryiskyeldkafsdrntliiyldkvshseddclafkvhqyfnveliqpgavkvy
ayynleesctrfyhpekedgklnklcrdelcrcaeencfiqkdkvtleerldkacepgvd
yvyktrlvkvqlsndfdeyimaieqtiksgsdevqvgqqrtfispikcrealkleekkhy
lmwglssdfwgekpnlsyiigkdtwvehwpeedecqdeenqkqcqdlgaftesmvvfgcp
n

  • Chain 'C':
    Sequence, based on SEQRES records:
    >2xwbC (C:)
spmysiitpnilrleseetmvleahdaqgdvpvtvtvhdfpgkklvlssektvltpatnh
mgnvtftipanrefksekgrnkfvtvqatfgtqvvekvvlvslqsgylfiqtdktiytpg
stvlyriftvnhkllpvgrtvmvnienpegipvkqdslssqnqlgvlplswdipelvnmg
qwkirayyenspqqvfstefevkeyvlpsfeviveptekfyyiynekglevtitarflyg
kkvegtafvifgiqdgeqrislpeslkripiedgsgevvlsrkvlldgvqnpraedlvgk
slyvsatvilhsgsdmvqaersgipivtspyqihftktpkyfkpgmpfdlmvfvtnpdgs
payrvpvavqgedtvqsltqgdgvaklsinthpsqkplsitvrtkkqelseaeqatrtmq
alpystvgnsnnylhlsvlrtelrpgetlnvnfllrmdraheakiryytylimnkgrllk
agrqvrepgqdlvvlplsittdfipsfrlvayytligasgqrevvadsvwvdvkdscvgs
lvvksgqsedrqpvpgqqmtlkiegdhgarvvlvavdkgvfvlnkknkltqskiwdvvek
adigctpgsgkdyagvfsdagltftsssgqqtaqraelqcpq

    Sequence, based on observed residues (ATOM records):
    >2xwbC (C:)
spmysiitpnilrleseetmvleahdaqgdvpvtvtvhdfpgkklvlssektvltpatnh
mgnvtftipanrefkkgrnkfvtvqatfgtqvvekvvlvslqsgylfiqtdktiytpgst
vlyriftvnhkllpvgrtvmvnienpegipvkqdslssqnqlgvlplswdipelvnmgqw
kirayyenspqqvfstefevkeyvlpsfeviveptekfyyiynekglevtitarflygkk
vegtafvifgiqdgeqrislpeslkripiedgsgevvlsrkvlldgvqnpraedlvgksl
yvsatvilhsgsdmvqaersgipivtspyqihftktpkyfkpgmpfdlmvfvtnpdgspa
yrvpvavqgedtvqsltqgdgvaklsinthpsqkplsitvrtkkqelseaeqatrtmqal
pystvgnsnnylhlsvlrtelrpgetlnvnfllrmdraheakiryytylimnkgrllkag
rqvrepgqdlvvlplsittdfipsfrlvayytligasgqrevvadsvwvdvkdscvgslv
vksgqsedrqpvpgqqmtlkiegdhgarvvlvavdkgvfvlnkknkltqskiwdvvekad
igctpgsgkdyagvfsdagltftsssgqqtaqraelqcpq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2xwbD (D:)
dediiaeenivsrsefpeswlwnvedlkeppkngistklmniflkdsittweilavsmsd
kkgicvadpfevtvmqdffidlrlpysvvrneqveiravlynyrqnqelkvrvellhnpa
fcslattkrrhqqtvtippksslsvpyvivplktglqevevkaavyhhfisdgvrkslkv
vpegirmnktvavrtldperlgregvqkedippadlsdqvpdtesetrillqgtpvaqmt
edavdaerlkhlivtpsgcgeenmigmtptviavhyldeteqwekfglekrqgalelikk
gytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilek
qkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitk
agdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynve
atsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdapdhqe
lnldvslqlpsrsskithrihwesasllrseetkenegftvtaegkgqgtlsvvtmyhak
akdqltcnkfdlkvtikpapetekrpqdakntmileictryrgdqdatmsildismmtgf
apdtddlkqlangvdryiskyeldkafsdrntliiyldkvshseddclafkvhqyfnvel
iqpgavkvyayynleesctrfyhpekedgklnklcrdelcrcaeencfiqksddkvtlee
rldkacepgvdyvyktrlvkvqlsndfdeyimaieqtiksgsdevqvgqqrtfispikcr
ealkleekkhylmwglssdfwgekpnlsyiigkdtwvehwpeedecqdeenqkqcqdlga
ftesmvvfgcpn

    Sequence, based on observed residues (ATOM records):
    >2xwbD (D:)
dediiaeenivsrsefpeswlwnvedlkeppkngistklmniflkdsittweilavsmsd
kkgicvadpfevtvmqdffidlrlpysvvrneqveiravlynyrqnqelkvrvellhnpa
fcslattkrrhqqtvtippksslsvpyvivplktglqevevkaavyhhfisdgvrkslkv
vpegirmnktvavrtldperlgregvqkedippadlsdqvpdtesetrillqgtpvaqmt
edavdaerlkhlivtpsgcgeenmigmtptviavhyldeteqwekfglekrqgalelikk
gytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilek
qkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitk
agdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynve
atsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdapdhqe
lnldvslqlpsrsskithrihwesasllrseetkenegftvtaegkgqgtlsvvtmyhak
akdqltcnkfdlkvtikpapkntmileictryrgdqdatmsildismmtgfapdtddlkq
langvdryiskyeldkafsdrntliiyldkvshseddclafkvhqyfnveliqpgavkvy
ayynleesctrfyhpekedgklnklcrdelcrcaeencfiqkdkvtleerldkacepgvd
yvyktrlvkvqlsndfdeyimaieqtiksgsdevqvgqqrtfispikcrealkleekkhy
lmwglssdfwgekpnlsyiigkdtwvehwpeedecqdeenqkqcqdlgaftesmvvfgcp
n

  • Chain 'F':
    Sequence, based on SEQRES records:
    >2xwbF (F:)
gscslegveikggsfrllqegqaleyvcpsgfypypvqtrtcrstgswstlktqdqktvr
kaecraihcprphdfengeywprspyynvsdeisfhcydgytlrgsanrtcqvngrwsgq
taicdngagycsnpgipigtrkvgsqyrledsvtyhcsrgltlrgsqrrtcqeggswsgt
epscqdsfmydtpqevaeaflssltetiegvdaedghgpgeqqkrkivldpsgsmniylv
ldgsgsigasdftgakkclvnliekvasygvkpryglvtyatypkiwvkvseadssnadw
vtkqlneinyedhklksgtntkkalqavysmmswpddvppegwnrtrhviilmtdglhnm
ggdpitvideirdllyigkdrknpredyldvyvfgvgplvnqvninalaskkdneqhvfk
vkdmenledvfyqmidesqslslcgmvwehrkgtdyhkqpwqakisvirpskghescmga
vvseyfvltaahcftvddkehsikvsvggekrdleievvlfhpnyningkkeagipefyd
ydvaliklknklkygqtirpiclpctegttralrlpptttcqqqkeellpaqdikalfvs
eeekkltrkevyikngdkkgscerdaqyapgydkvkdisevvtprflctggvspyadpnt
crgdsggplivhkrsrfiqvgviswgvvdvcknqkrqkqvpahardfhinlfqvlpwlke
klqdedlgflaa

    Sequence, based on observed residues (ATOM records):
    >2xwbF (F:)
gscslegveikggsfrllqegqaleyvcpsgfypypvqtrtcrstgswstlktqdqktvr
kaecraihcprphdfengeywprspyynvsdeisfhcydgytlrgsanrtcqvngrwsgq
taicdngagycsnpgipigtrkvgsqyrledsvtyhcsrgltlrgsqrrtcqeggswsgt
epscqdsfmydtpqevaeaflssltetiegvdaepsgsmniylvldgsgsigasdftgak
kclvnliekvasygvkpryglvtyatypkiwvkvseadssnadwvtkqlneinyedhklk
sgtntkkalqavysmmswpdppegwnrtrhviilmtdglhnmggdpitvideirdllyig
kdrknpredyldvyvfgvgplvnqvninalaskkdneqhvfkvkdmenledvfyqmides
qslslcgmvwehrkgtdyhkqpwqakisvirpskghescmgavvseyfvltaahcftvdd
kehsikvsvggekrdleievvlfhpnyningkkeagipefydydvaliklknklkygqti
rpiclpctegttralrlpptttcqqqkeellpaqdikalfvseeekkltrkevyikngdk
kgscerdaqyapgydkvkdisevvtprflctggvspyadpntcrgdsggplivhkrsrfi
qvgviswgvvdvcknqkrqkqvpahardfhinlfqvlpwlkeklqdedlgflaa

  • Chain 'H':
    Sequence, based on SEQRES records:
    >2xwbH (H:)
gscslegveikggsfrllqegqaleyvcpsgfypypvqtrtcrstgswstlktqdqktvr
kaecraihcprphdfengeywprspyynvsdeisfhcydgytlrgsanrtcqvngrwsgq
taicdngagycsnpgipigtrkvgsqyrledsvtyhcsrgltlrgsqrrtcqeggswsgt
epscqdsfmydtpqevaeaflssltetiegvdaedghgpgeqqkrkivldpsgsmniylv
ldgsgsigasdftgakkclvnliekvasygvkpryglvtyatypkiwvkvseadssnadw
vtkqlneinyedhklksgtntkkalqavysmmswpddvppegwnrtrhviilmtdglhnm
ggdpitvideirdllyigkdrknpredyldvyvfgvgplvnqvninalaskkdneqhvfk
vkdmenledvfyqmidesqslslcgmvwehrkgtdyhkqpwqakisvirpskghescmga
vvseyfvltaahcftvddkehsikvsvggekrdleievvlfhpnyningkkeagipefyd
ydvaliklknklkygqtirpiclpctegttralrlpptttcqqqkeellpaqdikalfvs
eeekkltrkevyikngdkkgscerdaqyapgydkvkdisevvtprflctggvspyadpnt
crgdsggplivhkrsrfiqvgviswgvvdvcknqkrqkqvpahardfhinlfqvlpwlke
klqdedlgflaa

    Sequence, based on observed residues (ATOM records):
    >2xwbH (H:)
gscslegveikggsfrllqegqaleyvcpsgfypypvqtrtcrstgswstlktqdqktvr
kaecraihcprphdfengeywprspyynvsdeisfhcydgytlrgsanrtcqvngrwsgq
taicdngagycsnpgipigtrkvgsqyrledsvtyhcsrgltlrgsqrrtcqeggswsgt
epscqdsfmydtpqevaeaflssltetiegvdaeddpsgsmniylvldgsgsigasdftg
akkclvnliekvasygvkpryglvtyatypkiwvkvseadssnadwvtkqlneinyedhk
lksgtntkkalqavysmmswpwnrtrhviilmtdglhnmggdpitvideirdllyigkdr
knpredyldvyvfgvgplvnqvninalaskkdneqhvfkvkdmenledvfyqmidesqsl
slcgmvwehrkgtdyhkqpwqakisvirpskghescmgavvseyfvltaahcftvddkeh
sikvsvggekrdleievvlfhpnyningkkeagipefydydvaliklknklkygqtirpi
clpctegttralrlpptttcqqqkeellpaqdikalfvseeekkltrkevyikngdkkgs
cerdaqyapgydkvkdisevvtprflctggvspyadpntcrgdsggplivhkrsrfiqvg
viswgvvdvcknqkrqkqvpahardfhinlfqvlpwlkeklqdedlgflaa

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records:
    >2xwbI (I:)
ilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahcledaadgkvqvllgahsl
sqpepskrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapg
tlcdvagwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsck
gdaggplvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvla

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records:
    >2xwbJ (J:)
ilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahcledaadgkvqvllgahsl
sqpepskrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapg
tlcdvagwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsck
gdaggplvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvla