PDB entry 2xtj
View 2xtj on RCSB PDB site
Description: The crystal structure of PCSK9 in complex with 1D05 Fab
Class: hydrolase/antibody
Keywords: hydrolase-antibody complex, serine protease, ldl-c, ldlr, egf-a, hypercholesterolemia
Deposited on
2010-10-10, released
2010-11-03
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-08, with a file datestamp of
2019-05-03.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proprotein convertase subtilisin/kexin type 9
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2xtja_ - Chain 'B':
Compound: fab from a human monoclonal antibody, 1d05
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2xtjb_ - Chain 'C':
Compound: fab from a human monoclonal antibody, 1d05
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2xtjc_ - Chain 'D':
Compound: fab from a human monoclonal antibody, 1d05
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2xtjd_ - Chain 'E':
Compound: fab from a human monoclonal antibody, 1d05
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'P':
Compound: proprotein convertase subtilisin-kexin type 9
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: CA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2xtjA (A:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlilfsakdvineawfpedqrvltpnlvaalppsthgaa
gtaaashhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2xtjA (A:)
pwnslvevylldtsiqsdhreiegrvmvtdfenvpeedqaskcdshgthlagvvsgrdag
vakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllplaggysrvlnaa
cqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlgtlgtnfgrcvd
lfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepeltlaelrqrlilfsa
kd
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>2xtjB (B:)
diqmtqspsslsasvgdrvtitcrasqgirsalnwyqqkpgkapklliyngstlqsgvps
rfsgsgsgtdftltisslqpedfavyycqqfdgdptfgqgtkveikr
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2xtjC (C:)
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds
kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgea
Sequence, based on observed residues (ATOM records): (download)
>2xtjC (C:)
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds
kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrge
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>2xtjD (D:)
qvqlvqsgaevkkpgssvkvsckasggtfnshaiswvrqapgqglewmgginpilgiany
aqkfqgrvtitadeststaymelsslrsedtavyycarhyeiqigrygmnvyylmyrfas
wgqgtlvtvss
- Chain 'E':
No sequence available.
- Chain 'P':
No sequence available.