PDB entry 2xrw
View 2xrw on RCSB PDB site
Description: Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
Class: transcription
Keywords: transcription, mapk signaling pathways, linear binding motif
Deposited on
2010-09-23, released
2011-09-28
The last revision prior to the SCOPe 2.05 freeze date was dated
2012-10-24, with a file datestamp of
2012-10-19.
Experiment type: XRAY
Resolution: 1.33 Å
R-factor: 0.1656
AEROSPACI score: 0.74
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot A1L4K2 (2-364)
- expression tag (1)
- expression tag (365)
Domains in SCOPe 2.05: d2xrwa_ - Chain 'B':
Compound: nuclear factor of activated t-cells, cytoplasmic 3
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: ANP, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2xrwA (A:)
mgsrskrdnnfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsr
pfqnqthakrayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqvi
qmeldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagts
fmmtpyvvtryyrapevilgmgykenvdiwsvgcimgemikggvlfpgtdhidqwnkvie
qlgtpcpefmkklqptvrtyvenrpkyagysfeklfpdvlfpadsehnklkasqardlls
kmlvidaskrisvdealqhpyinvwydpseaeapppkipdkqlderehtieewkeliyke
vmdlehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2xrwA (A:)
gsrskrdnnfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrp
fqnqthakrayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviq
meldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglryyrapev
ilgmgykenvdiwsvgcimgemikggvlfpgtdhidqwnkvieqlgtpcpefmkklqptv
rtyvenrpkyagysfeklfpdvlfpadsehnklkasqardllskmlvidaskrisvdeal
qhpyinvwydpseaeapppkipdkqlderehtieewkeliykevmdleh
- Chain 'B':
No sequence available.