PDB entry 2xqw

View 2xqw on RCSB PDB site
Description: structure of factor h domains 19-20 in complex with complement c3d
Class: immune system
Keywords: immune system, complement alternative pathway, atypical hemolytic uremic syndrome, ahus, cfh, fh, c3b
Deposited on 2010-09-07, released 2011-02-02
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-08-17, with a file datestamp of 2011-08-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.2026
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Complement C3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (2-293)
      • expression tag (0-1)
      • engineered mutation (16)
    Domains in SCOPe 2.03: d2xqwa_
  • Chain 'B':
    Compound: Complement C3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (2-293)
      • expression tag (0-1)
      • engineered mutation (16)
    Domains in SCOPe 2.03: d2xqwb_
  • Chain 'C':
    Compound: complement factor h
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08603 (Start-132)
      • engineered mutation (20)
      • engineered mutation (40)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2xqwA (A:)
mldaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkgy
tqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekqk
pdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitkag
dfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynveat
syallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2xqwB (B:)
mldaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkgy
tqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekqk
pdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitkag
dfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynveat
syallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'C':
    No sequence available.