PDB entry 2xp2

View 2xp2 on RCSB PDB site
Description: Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)
Class: transferase
Keywords: crizotinib, transferase
Deposited on 2010-08-24, released 2010-09-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-15, with a file datestamp of 2019-05-10.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2xp2a_
  • Heterogens: VGH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xp2A (A:)
mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
yctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >2xp2A (A:)
npnycfagktssisdlkevprknitlirglgafgevyegqvsplqvavktlpevcseqde
ldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyramlp
vkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppk
ncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey