PDB entry 2xnb

View 2xnb on RCSB PDB site
Description: Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
Class: transferase
Keywords: cell cycle, transferase, cdk9 inhibitor
Deposited on 2010-08-01, released 2010-11-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-03-28, with a file datestamp of 2012-03-23.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.21557
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2xnba_
  • Heterogens: Y8L, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xnbA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >2xnbA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtegvpstaireisllkelnhpn
ivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshr
vlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyyst
avdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpk
warqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl