PDB entry 2xn5

View 2xn5 on RCSB PDB site
Description: crystal structure of thyroxine-binding globulin complexed with furosemide
Deposited on 2010-07-30, released 2011-02-16
The last revision was dated 2011-05-11, with a file datestamp of 2011-05-06.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.20574
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thyroxine-binding globulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05543
      • engineered mutation (334-344)
  • Chain 'B':
    Compound: thyroxine-binding globulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FUN, CA, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2xn5A (A:)
ssqpnatlykmssinadfafnlyrrftvetpdkniffspvsisaalvmlsfgaccstqte
ivetlgfnltdtpmveiqhgfqhlicslnfpkkelelqignalfigkhlkplakflndvk
tlyetevfstdfsnisaakqeinshvemqtkgkvvgliqdlkpntimvlvnyihfkaqwa
npfdpsktedsssflidktttvqvpmmhqmeqyyhlvdmelnctvlqmdysknalalfvl
pkegqmesveaamssktlkkwnrllqkgwvdlfvpkfsisatydlgatllkmgiqhayse
nadfsgltednglklsnaahkavlhigekgteaagamfleaiprsipntf

    Sequence, based on observed residues (ATOM records):
    >2xn5A (A:)
pnatlykmssinadfafnlyrrftvetpdkniffspvsisaalvmlsfgaccstqteive
tlgfnltdtpmveiqhgfqhlicslnfpkkelelqignalfigkhlkplakflndvktly
etevfstdfsnisaakqeinshvemqtkgkvvgliqdlkpntimvlvnyihfkaqwanpf
dpsktedsssflidktttvqvpmmhqmeqyyhlvdmelnctvlqmdysknalalfvlpke
gqmesveaamssktlkkwnrllqkgwvdlfvpkfsisatydlgatllkmgiqhaysenad
fsgltednglklsnaahkavlhigekgteaagamfleaiprs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2xn5B (B:)
lhpiiqidrsfmllilerstrsilflgkvvnptea

    Sequence, based on observed residues (ATOM records):
    >2xn5B (B:)
hpiiqidrsfmllilerstrsilflgkvvnptea