PDB entry 2xhv

View 2xhv on RCSB PDB site
Description: hcv-j4 ns5b polymerase point mutant orthorhombic crystal form
Class: transferase
Keywords: replication, transcription, transferase
Deposited on 2010-06-21, released 2010-08-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-03-30, with a file datestamp of 2011-03-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.1722
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (1-End)
      • engineered mutation (556)
    Domains in SCOPe 2.08: d2xhva_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (1-End)
      • engineered mutation (556)
    Domains in SCOPe 2.08: d2xhvb_
  • Heterogens: SO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xhvA (A:)
asmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhi
rsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
taacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsysp
geinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpi
paasqldlsgwfvagykggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2xhvA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagykggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xhvB (B:)
asmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhi
rsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
taacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsysp
geinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpi
paasqldlsgwfvagykggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2xhvB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagykggdiyhs