PDB entry 2xhr

View 2xhr on RCSB PDB site
Description: structure of hsp90 with small molecule inhibitor bound
Class: chaperone
Keywords: chaperone, ATP binding domain, n-terminal domain, stress response
Deposited on 2010-06-21, released 2010-09-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-09-01, with a file datestamp of 2010-08-27.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.2532
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock protein HSP 90-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2xhra_
  • Heterogens: C0P, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xhrA (A:)
mgsshhhhhhssglvprgshmdqpmeeeevetfafqaeiaqlmsliintfysnkeiflre
lisnssdaldkiryesltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnl
gtiaksgtkafmealqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessag
gsftvrtdtgepmgrgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerd
kevsddeae

    Sequence, based on observed residues (ATOM records): (download) 
    >2xhrA (A:)
vetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgkel
hinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfgv
gfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqte
yleerrikeivkkhsqfigypitlfvek