PDB entry 2xhi
View 2xhi on RCSB PDB site
Description: separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase
Class: lyase/DNA
Keywords: lyase-DNA complex, separation-of-function mutant, helix-hairpin-helix, DNA repair
Deposited on
2010-06-16, released
2011-01-26
The last revision prior to the SCOPe 2.03 freeze date was dated
2011-01-26, with a file datestamp of
2011-01-21.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: 0.23113
AEROSPACI score: 0.54
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: N-glycosylase/DNA lyase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot O15527
- engineered mutation (263)
- engineered mutation (267)
- engineered mutation (282)
Domains in SCOPe 2.03: d2xhia1, d2xhia2 - Chain 'B':
Compound: 5'-d(*gp*gp*tp*ap*gp*ap*cp*cp*tp*gp*gp*ap*cp*gp*c)-3'
- Chain 'C':
Compound: 5'-d(*gp*cp*gp*tp*cp*cp*ap*(8og)p*gp*tp*cp*tp*ap*cp*c)-3'
- Heterogens: CA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2xhiA (A:)
mgshhhhhhsqdpnsmparallprrmghrtlastpalwasipcprselrldlvlpsgqsf
rwreqspahwsgvladqvwtltqteeqlhctvyrgdksqasrptpdeleavrkyfqldvt
laqlyhhwgsvdshfqevaqkfqgvrllrqdpieclfsficssnnniaritgmverlcqa
fgprliqlddvtyhgfpslqalagpeveahlrklglgyraryvsasaraileeqgglawl
qqlressyeeahkalcilpgvgtcvadkiclmaldkpqavpvnvhmwhiaqrdyswhptt
sqakgpspqtnkelgnffrslwgpyagwaqavlfsadlrqsrhaqeppakrrkgskgpeg
Sequence, based on observed residues (ATOM records): (download)
>2xhiA (A:)
rmghrtlastpalwasipcprselrldlvlpsgqsfrwreqspahwsgvladqvwtltqt
eeqlhctvyrgdksqasrptpdeleavrkyfqldvtlaqlyhhwgsvdshfqevaqkfqg
vrllrqdpieclfsficssnnniaritgmverlcqafgprliqlddvtyhgfpslqalag
peveahlrklglgyraryvsasaraileeqgglawlqqlressyeeahkalcilpgvgtc
vadkiclmaldkpqavpvnvhmwhiaqrdyswhpttsqakgpspqtnkelgnffrslwgp
yagwaqavlfsadlrq
- Chain 'B':
No sequence available.
- Chain 'C':
No sequence available.