PDB entry 2xfk
View 2xfk on RCSB PDB site
Description: human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)(phenyl)amino)benzamide
Class: hydrolase
Keywords: zymogen, protease, hydrolase
Deposited on
2010-05-24, released
2010-07-07
The last revision prior to the SCOPe 2.03 freeze date was dated
2010-07-28, with a file datestamp of
2010-07-23.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.16456
AEROSPACI score: 0.53
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Beta-secretase 1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P56817
- engineered mutation (92)
- engineered mutation (111)
- engineered mutation (293)
Domains in SCOPe 2.03: d2xfka_ - Heterogens: AA9, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2xfkA (A:)
vemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsst
yrdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegil
glayaeiarpddslepffdslvkqthvpnlfslqlcgagfplqqsevlasvggsmiiggi
dhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkk
vfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfrit
ilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsac
hvhdefrtaavegpfvtldmedcgynipqtde
Sequence, based on observed residues (ATOM records): (download)
>2xfkA (A:)
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcvggsmiiggidhslytgslwytpir
rewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaasst
ekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfritilpqqylrpvedvat
sqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpf
vtldmedcgyni