PDB entry 2xfh

View 2xfh on RCSB PDB site
Description: Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.
Class: oxidoreductase
Keywords: monoxygenase, erythromycin a biosynthesis, oxidoreductase
Deposited on 2010-05-24, released 2010-09-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.18358
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: erythromycin b/d c-12 hydroxylase
    Species: Saccharopolyspora erythraea [TaxId:1836]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48635 (Start-410)
      • engineered mutation (343)
    Domains in SCOPe 2.08: d2xfha_
  • Heterogens: HEM, CL6, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xfhA (A:)
mfadvettccarrtlttidevpgmadetalldwlgtmrekqpvwqdrygvwhvfrhadvq
tvlrdtatfssdptrviegasptpgmiheidppehralrkvvssaftprtisdleprird
vtrslladagesfdlvdvlafplpvtivaellglppmdheqfgdwsgalvdiqmddptdp
alaeriadvlnpltaylkarcaerradpgddlisrlvlaevdgralddeeaanfstalll
aghitttvllgnivrtldehpahwdaaaedpgripaiveevlryrppfpqmqrtttkate
vagvpipadvmvntwvlsanrdsdahddpdrfdpsrksggaaqlsfghgvhfclgaplar
lenrvaleeiiarfgrltvdrdderlrhfeqivlgtrhlpvlagssprqsa

    Sequence, based on observed residues (ATOM records): (download) 
    >2xfhA (A:)
idevpgmadetalldwlgtmrekqpvwqdrygvwhvfrhadvqtvlrdtatfssdptrvi
egasptpgmiheidppehralrkvvssaftprtisdleprirdvtrslladagesfdlvd
vlafplpvtivaellglppmdheqfgdwsgalvdiqmddptdpalaeriadvlnpltayl
karcaerradpgddlisrlvlaevdgralddeeaanfstalllaghitttvllgnivrtl
dehpahwdaaaedpgripaiveevlryrppfpqmqrtttkatevagvpipadvmvntwvl
sanrdsdahddpdrfdpsrksggaaqlsfghgvhfclgaplarlenrvaleeiiarfgrl
tvdrdderlrhfeqivlgtrhlpvlagssprqsa