PDB entry 2xct

View 2xct on RCSB PDB site
Description: the twinned 3.35a structure of s. aureus gyrase complex with ciprofloxacin and dna
Deposited on 2010-04-25, released 2010-08-25
The last revision was dated 2010-08-25, with a file datestamp of 2010-08-20.
Experiment type: XRAY
Resolution: 3.35 Å
R-factor: 0.1692
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:158879]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937 (137-End)
      • insertion (135-136)
      • engineered mutation (323)
    • Uniprot Q99XG5 (Start-691)
  • Chain 'D':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:158879]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937
      • insertion (135)
      • engineered mutation (323)
    • Uniprot Q99XG5 (Start-691)
  • Chain 'E':
    Compound: 5'-d(tp*gp*tp*gp*cp*gp*gp*t)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'F':
    Compound: 5'-d(ap*gp*cp*cp*gp*tp*ap*g)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'G':
    Compound: 5'-d(gp*tp*ap*cp*cp*cp*ap*cp*gp*gp*cp*t)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'H':
    Compound: 5'-d(gp*tp*ap*cp*ap*cp*cp*gp*cp*ap*cp*a)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'S':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:158879]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937
      • insertion (135)
      • engineered mutation (323)
    • Uniprot Q99XG5 (Start-691)
  • Chain 'U':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:158879]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937
      • insertion (135)
      • engineered mutation (323)
    • Uniprot Q99XG5 (Start-691)
  • Chain 'V':
    Compound: 5'-d(tp*gp*tp*gp*cp*gp*gp*t)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'W':
    Compound: 5'-d(ap*gp*cp*cp*gp*tp*ap*g)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'X':
    Compound: 5'-d(gp*tp*ap*cp*cp*cp*ap*cp*gp*gp*cp*t)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'Y':
    Compound: 5'-d(gp*tp*ap*cp*ap*cp*cp*gp*cp*ap*cp*a)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: MN, CPF

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2xctB (B:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlm
gdvvenrrqfiednavyanldfaelpqsrinernitsemresfldyamsvivaralpdvr
dglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdssiyeamvrmaqdfsy
ryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsv
lparfpnllangasgiavgmatnipphnltelingvlslsknpdisiaelmediegpdfp
taglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiae
lvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialv
ngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistir
esdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletil
adeevllqlvrdelteirdrfgddrrteiqlg

    Sequence, based on observed residues (ATOM records):
    >2xctB (B:)
kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnnn
eirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagy
vyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrr
qfiednanernitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdk
sykksarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamr
ftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatn
ipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiq
mrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgv
rvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktv
vrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqa
qaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgd
drrteiqlg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2xctD (D:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlm
gdvvenrrqfiednavyanldfaelpqsrinernitsemresfldyamsvivaralpdvr
dglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdssiyeamvrmaqdfsy
ryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsv
lparfpnllangasgiavgmatnipphnltelingvlslsknpdisiaelmediegpdfp
taglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiae
lvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialv
ngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistir
esdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletil
adeevllqlvrdelteirdrfgddrrteiqlg

    Sequence, based on observed residues (ATOM records):
    >2xctD (D:)
kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnnn
eirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagy
vyiaqpptkglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqf
iednavynernitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdk
sykksarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamr
ftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatn
ipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiq
mrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgv
rvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktv
vrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqa
qaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgd
drrteiqlg

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'S':
    Sequence, based on SEQRES records:
    >2xctS (S:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlm
gdvvenrrqfiednavyanldfaelpqsrinernitsemresfldyamsvivaralpdvr
dglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdssiyeamvrmaqdfsy
ryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsv
lparfpnllangasgiavgmatnipphnltelingvlslsknpdisiaelmediegpdfp
taglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiae
lvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialv
ngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistir
esdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletil
adeevllqlvrdelteirdrfgddrrteiqlg

    Sequence, based on observed residues (ATOM records):
    >2xctS (S:)
kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnnn
eirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagy
vyiaqpptglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfi
ednavyarnitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksy
kksarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrft
earmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnip
phnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmr
sravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrv
vidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvr
rrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqa
ildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddr
rteiqlg

  • Chain 'U':
    Sequence, based on SEQRES records:
    >2xctU (U:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlm
gdvvenrrqfiednavyanldfaelpqsrinernitsemresfldyamsvivaralpdvr
dglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdssiyeamvrmaqdfsy
ryplvdgqgnfgsmdgdgaaamrftearmtkitlellrdinkdtidfidnydgnerepsv
lparfpnllangasgiavgmatnipphnltelingvlslsknpdisiaelmediegpdfp
taglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiae
lvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialv
ngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistir
esdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletil
adeevllqlvrdelteirdrfgddrrteiqlg

    Sequence, based on observed residues (ATOM records):
    >2xctU (U:)
ladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnnne
irqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyv
yiaqpptkglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfi
ednavynitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykk
sarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftea
rmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipph
nltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsr
avieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvi
dvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrr
tqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqail
dmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrt
eiqlg

  • Chain 'V':
    No sequence available.

  • Chain 'W':
    No sequence available.

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.