PDB entry 2xcr

View 2xcr on RCSB PDB site
Description: the 3.5a crystal structure of the catalytic core (b'a' region) of staphylococcus aureus dna gyrase complexed with gsk299423 and dna
Deposited on 2010-04-25, released 2010-08-04
The last revision was dated 2010-08-25, with a file datestamp of 2010-08-20.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: 0.2102
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937 (Start-235)
      • engineered mutation (357)
    • Uniprot Q99XG5 (236-725)
  • Chain 'D':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937 (Start-235)
      • engineered mutation (357)
    • Uniprot Q99XG5 (236-725)
  • Chain 'E':
    Compound: 5'-d(*5ua*gp*cp*cp*gp*tp*ap*gp*gp*gp*cp*cp*cp*tp*ap*cp*gp *gp*cp*tp)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'F':
    Compound: 5'-d(*5ua*gp*cp*cp*gp*tp*ap*gp*gp*gp*cp*cp*cp*tp*ap*cp*gp *gp*cp*tp)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'S':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937 (Start-235)
      • engineered mutation (357)
    • Uniprot Q99XG5 (236-End)
  • Chain 'U':
    Compound: DNA gyrase subunit b, DNA gyrase subunit a
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P66937 (Start-235)
      • engineered mutation (357)
    • Uniprot Q99XG5 (236-End)
  • Chain 'V':
    Compound: 5'-d(*ap*gp*cp*cp*gp*tp*ap*gp*gp*gp*cp*cp*cp*tp*ap*cp*gp *gp*cp*tp)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'W':
    Compound: 5'-d(*ap*gp*cp*cp*gp*tp*ap*gp*gp*gp*cp*cp*cp*tp*ap*cp*gp *gp*cp*tp)-3'
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: RXV

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2xcrB (B:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemna
dqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelp
qsrinernitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksyk
ksarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrfte
armtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipp
hnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrs
ravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvv
idvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrr
rtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqai
ldmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrr
teiqlg

    Sequence, based on observed residues (ATOM records):
    >2xcrB (B:)
kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnnn
eirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagy
vyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemnadqlwettm
npehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelpqsrinern
itsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivgd
vmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkitl
ellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipphnltelin
gvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieerg
ggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdan
asvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrk
akdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrl
tglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiqlg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2xcrD (D:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemna
dqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelp
qsrinernitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksyk
ksarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrfte
armtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipp
hnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrs
ravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvv
idvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrr
rtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqai
ldmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrr
teiqlg

    Sequence, based on observed residues (ATOM records):
    >2xcrD (D:)
gkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnn
neirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieag
yvyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemnadqlwett
mnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelpqsriner
nitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivg
dvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkit
lellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipphnlteli
ngvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieer
gggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkda
nasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlr
kakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrr
ltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiqlg

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'S':
    Sequence, based on SEQRES records:
    >2xcrS (S:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemna
dqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelp
qsrinernitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksyk
ksarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrfte
armtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipp
hnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrs
ravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvv
idvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrr
rtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqai
ldmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrr
teiqlg

    Sequence, based on observed residues (ATOM records):
    >2xcrS (S:)
gkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnn
neirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieag
yvyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemnadqlwett
mnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelpqsriner
nitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivg
dvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkit
lellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipphnlteli
ngvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieer
gggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkda
nasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlr
kakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrr
ltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql

  • Chain 'U':
    Sequence, based on SEQRES records:
    >2xcrU (U:)
mdvaslpgkladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekar
ldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfm
rplieagyvyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemna
dqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelp
qsrinernitsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksyk
ksarivgdvmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrfte
armtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipp
hnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrs
ravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvv
idvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrr
rtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqai
ldmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrr
teiqlg

    Sequence, based on observed residues (ATOM records):
    >2xcrU (U:)
kladcsskspeeceiflvegdsaggstksgrdsrtqailplrgkilnvekarldrilnnn
eirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagy
vyiaqpplykltqgkqkyyvyndreldklkselnptpkwsiarykglgemnadqlwettm
npehrallqvkledaieadqtfemlmgdvvenrrqfiednavyanldfaelpqsrinern
itsemresfldyamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivgd
vmgkyhphgdssiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamrftearmtkitl
ellrdinkdtidfidnydgnerepsvlparfpnllangasgiavgmatnipphnltelin
gvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieerg
ggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdan
asvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrk
akdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrl
tglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql

  • Chain 'V':
    No sequence available.

  • Chain 'W':
    No sequence available.