PDB entry 2xcn

View 2xcn on RCSB PDB site
Description: crystal structure of hcv ns3 protease with a boronate inhibitor
Deposited on 2010-04-23, released 2010-06-02
The last revision was dated 2010-06-16, with a file datestamp of 2010-06-11.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: 0.18674
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NS3 protease
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91RS4 (10-189)
      • conflict (49)
      • conflict (100)
  • Chain 'B':
    Compound: NS3 protease
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91RS4 (Start-189)
      • conflict (49)
      • conflict (100)
  • Chain 'C':
    Compound: ns4a
    Species: Hepatitis C virus, synthetic [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9WU77 (2-20)
      • expression tag (1)
      • expression tag (21)
  • Chain 'D':
    Compound: ns4a
    Species: Hepatitis C virus, synthetic [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: C8D, MG, ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2xcnA (A:)
asmtggqqmgapitayaqqtrgllgciitsltgrdknqvegevqivstatqtflatcing
vcwtvyhgagtrtiaspkgpviqmytnvdqdlvgwpapqgsrsltpctcgssdlylvtrh
advipvrrrgdsrgsllsprpisylkgssggpllcpaghavglfraavctrgvakavdfi
pvenlettmrgshhhhhh

    Sequence, based on observed residues (ATOM records):
    >2xcnA (A:)
apitayaqqtrgllgciitsltgrdknqvegevqivstatqtflatcingvcwtvyhgag
trtiaspkgpviqmytnvdqdlvgwpapqgsrsltpctcgssdlylvtrhadvipvrrrg
dsrgsllsprpisylkgssggpllcpaghavglfraavctrgvakavdfipvenlettmr

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2xcnB (B:)
asmtggqqmgapitayaqqtrgllgciitsltgrdknqvegevqivstatqtflatcing
vcwtvyhgagtrtiaspkgpviqmytnvdqdlvgwpapqgsrsltpctcgssdlylvtrh
advipvrrrgdsrgsllsprpisylkgssggpllcpaghavglfraavctrgvakavdfi
pvenlettmrgshhhhhh

    Sequence, based on observed residues (ATOM records):
    >2xcnB (B:)
qvegevqivstatqtflatcingvcwtvyhgagtrtiaspkgpviqmytnvdqdlvgwpa
pqgsrsltpctcgssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpa
ghavglfraavctrgvakavdfipvenlettmr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >2xcnC (C:)
kkgsvvivgrivlsgkpaiipkk

    Sequence, based on observed residues (ATOM records):
    >2xcnC (C:)
kgsvvivgrivlsgkpaiipk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2xcnD (D:)
kkgsvvivgrivlsgkpaiipkk

    Sequence, based on observed residues (ATOM records):
    >2xcnD (D:)
gsvvivgrivlsgkpa