PDB entry 2xch
View 2xch on RCSB PDB site
Description: crystal structure of pdk1 in complex with a pyrazoloquinazoline inhibitor
Class: transferase
Keywords: pi3-kinase signalling, transferase, serine/threonine-protein kinase, ATP-binding
Deposited on
2010-04-23, released
2010-07-28
The last revision prior to the SCOPe 2.05 freeze date was dated
2010-07-28, with a file datestamp of
2010-07-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.19061
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 3-phosphoinositide dependent protein kinase 1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2xcha_ - Heterogens: CKG, GOL, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2xchA (A:)
mdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsreyai
kilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngellky
irkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtakvl
speskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragneyli
fqkiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtwenl
hqqtppklt
Sequence, based on observed residues (ATOM records): (download)
>2xchA (A:)
qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
leylhgkgiihrdlkpenillnedmhiqitdfgtakvlsnsfvgtaqyvspellteksac
kssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvld
atkrlgceemegygplkahpffesvtwenlhqqtppklt