PDB entry 2xch

View 2xch on RCSB PDB site
Description: crystal structure of pdk1 in complex with a pyrazoloquinazoline inhibitor
Class: transferase
Keywords: pi3-kinase signalling, transferase, serine/threonine-protein kinase, ATP-binding
Deposited on 2010-04-23, released 2010-07-28
The last revision prior to the SCOPe 2.04 freeze date was dated 2010-07-28, with a file datestamp of 2010-07-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.19061
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2xcha_
  • Heterogens: CKG, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2xchA (A:)
    mdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsreyai
    kilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngellky
    irkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtakvl
    speskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragneyli
    fqkiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtwenl
    hqqtppklt
    

    Sequence, based on observed residues (ATOM records): (download)
    >2xchA (A:)
    qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
    vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
    leylhgkgiihrdlkpenillnedmhiqitdfgtakvlsnsfvgtaqyvspellteksac
    kssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvld
    atkrlgceemegygplkahpffesvtwenlhqqtppklt