PDB entry 2xc3

View 2xc3 on RCSB PDB site
Description: X-ray structure of Mycobacterium tuberculosis cyp125 bound to the reverse type I inhibitor
Class: oxidoreductase
Keywords: oxidoreductase, metal-binding
Deposited on 2010-04-16, released 2010-11-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: putative cytochrome p450 125
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63709
      • engineered mutation (419)
    Domains in SCOPe 2.08: d2xc3a_
  • Heterogens: HEM, RT8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xc3A (A:)
mhhhhhhmpspnlppgfdftdpaiyaerlpvaefaelrsaapiwwngqdpgkgggfhdgg
fwaitklndvkeisrhsdvfssyengviprfkndiaredievqrfvmlnmdaphhtrlrk
iisrgftpravgrlhdelqeraqkiaaeaaaagsgdfveqvscelplqaiagllgvpqed
rgklfhwsnemtgnedpeyahidpkassaeligyamkmaeekaknpaddivtqliqadid
geklsddefgffvvmlavagnettrnsitqgmmafaehpdqwelykkvrpetaadeivrw
atpvtafqrtalrdyelsgvqikkgqrvvmfyrsanfdeevfqdpftfnilrnpnphvgf
ggtgahyciganlarmtinlifnavadhmpdlkpisaperlrsgwlngikhwqvdytgrl
pvah

    Sequence, based on observed residues (ATOM records): (download) 
    >2xc3A (A:)
spnlppgfdftdpaiyaerlpvaefaelrsaapiwwngqdpgkgggfhdggfwaitklnd
vkeisrhsdvfssyengviprfkndiaredievqrfvmlnmdaphhtrlrkiisrgftpr
avgrlhdelqeraqkiaaeaaaagsgdfveqvscelplqaiagllgvpqedrgklfhwsn
emtgnedpeyahidpkassaeligyamkmaeekadivtqliqadidgeklsddefgffvv
mlavagnettrnsitqgmmafaehpdqwelykkvrpetaadeivrwatpvtafqrtalrd
yelsgvqikkgqrvvmfyrsanfdeevfqdpftfnilrnpnphvgfggtgahyciganla
rmtinlifnavadhmpdlkpisaperlrsgwlngikhwqvdytgrlpva