PDB entry 2xb2

View 2xb2 on RCSB PDB site
Description: crystal structure of the core mago-y14-eif4aiii-barentsz-upf3b assembly shows how the ejc is bridged to the nmd machinery
Deposited on 2010-04-03, released 2010-05-12
The last revision was dated 2010-06-23, with a file datestamp of 2010-06-18.
Experiment type: XRAY
Resolution: 3.4 Å
R-factor: 0.2204
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Eukaryotic initiation factor 4A-III
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Protein mago nashi homolog
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: RNA-binding protein 8A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: RNA poly-u-ribonucleotide
  • Chain 'F':
    Compound: putative regulator of nonsense transcripts 3b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2XB2 (0-2)
  • Chain 'G':
    Compound: regulator of nonsense transcripts 3b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: RNA poly-u-ribonucleotide
  • Chain 'S':
    Compound: Protein CASC3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: Protein CASC3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'U':
    Compound: regulator of nonsense transcripts 3b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'X':
    Compound: Eukaryotic initiation factor 4A-III
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Y':
    Compound: Protein mago nashi homolog
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Z':
    Compound: RNA-binding protein 8A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MG, ANP

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2xb2A (A:)
mattatmatsgsarkrllkeedmtkvefetseevdvtptfdtmglredllrgiyaygfek
psaiqqraikqiikgrdviaqsqsgtgktatfsisvlqcldiqvretqalilaptrelav
qiqkgllalgdymnvqchaciggtnvgedirkldygqhvvagtpgrvfdmirrrslrtra
ikmlvldeademlnkgfkeqiydvyrylppatqvvlisatlpheilemtnkfmtdpiril
vkrdeltlegikqffvavereewkfdtlcdlydtltitqavifcntkrkvdwltekmrea
nftvssmhgdmpqkeresimkefrsgasrvlistdvwargldvpqvsliinydlpnnrel
yihrigrsgrygrkgvainfvknddirilrdieqyystqidempmnvadli

    Sequence, based on observed residues (ATOM records):
    >2xb2A (A:)
dmtkvefetseevdvtptfdtmglredllrgiyaygfekpsaiqqraikqiikgrdviaq
sqsgtgktatfsisvlqcldiqvretqalilaptrelavqiqkgllalgdymnvqchaci
ggtnvgedirkldygqhvvagtpgrvfdmirrrslrtraikmlvldeademlnkgfkeqi
ydvyrylppatqvvlisatlpheilemtnkfmtdpirilvkrdeltlegikqffvavere
ewkfdtlcdlydtltitqavifcntkrkvdwltekmreanftvssmhgdmpqkeresimk
efrsgasrvlistdvwargldvpqvsliinydlpnnrelyihrigrsgrygrkgvainfv
knddirilrdieqyystqidempmnvadli

  • Chain 'C':
    Sequence, based on SEQRES records:
    >2xb2C (C:)
mesdfylryyvghkgkfgheflefefrpdgklryannsnykndvmirkeayvhksvmeel
kriiddseitkeddalwpppdrvgrqeleivigdehisfttskigslidvnqskdpeglr
vfyylvqdlkclvfsliglhfkikpi

    Sequence, based on observed residues (ATOM records):
    >2xb2C (C:)
dfylryyvghkgkfgheflefefrpdgklryannsnykndvmirkeayvhksvmeelkri
iddseitkeddalwpppdrvgrqeleivigdehisfttskigslidvnqskdpeglrvfy
ylvqdlkclvfsliglhfkikpi

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2xb2D (D:)
pqrsvegwilfvtgvheeateedihdkfaeygeiknihlnldrrtgylkgytlveyetyk
eaqaameglngqdlmgqpisvdwcfvrgpp

    Sequence, based on observed residues (ATOM records):
    >2xb2D (D:)
pqrsvegwilfvtgvheeateedihdkfaeygeiknihlnldrrtgylkgytlveyetyk
eaqaameglngqdlmgqpisvdwcfvrgp

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >2xb2F (F:)
aer

  • Chain 'G':
    Sequence, based on SEQRES records:
    >2xb2G (G:)
evvkrdrirnkdrpamqlyqpgarsrnrlcppddstksgdsaaerkqesgishrkeggee

    Sequence, based on observed residues (ATOM records):
    >2xb2G (G:)
irnkdrpamqlyqpg

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    Sequence, based on SEQRES records:
    >2xb2S (S:)
dtkstvtgerqsgdgqestepvenkvgkkgpkhldddedrknpayiprkglffehdlrgq
tqeeevrpkgrqrklwkdegrwehdkfredeqapksrqelialygydirsahnpddikpr
rirkprygsppqrdpnwngerlnkshrhqg

    Sequence, based on observed residues (ATOM records):
    >2xb2S (S:)
hldddedrknpayiprkglffehdlrgrwehdkfredeqapksrqelialygydirs

  • Chain 'T':
    Sequence, based on SEQRES records:
    >2xb2T (T:)
dtkstvtgerqsgdgqestepvenkvgkkgpkhldddedrknpayiprkglffehdlrgq
tqeeevrpkgrqrklwkdegrwehdkfredeqapksrqelialygydirsahnpddikpr
rirkprygsppqrdpnwngerlnkshrhqg

    Sequence, based on observed residues (ATOM records):
    >2xb2T (T:)
hldddedrknpayiprkglffehdlrgrwehdkfredeqapksrqelialygydirsah

  • Chain 'U':
    Sequence, based on SEQRES records:
    >2xb2U (U:)
evvkrdrirnkdrpamqlyqpgarsrnrlcppddstksgdsaaerkqesgishrkeggee

    Sequence, based on observed residues (ATOM records):
    >2xb2U (U:)
irnkdrpamqlyqpgar

  • Chain 'X':
    Sequence, based on SEQRES records:
    >2xb2X (X:)
mattatmatsgsarkrllkeedmtkvefetseevdvtptfdtmglredllrgiyaygfek
psaiqqraikqiikgrdviaqsqsgtgktatfsisvlqcldiqvretqalilaptrelav
qiqkgllalgdymnvqchaciggtnvgedirkldygqhvvagtpgrvfdmirrrslrtra
ikmlvldeademlnkgfkeqiydvyrylppatqvvlisatlpheilemtnkfmtdpiril
vkrdeltlegikqffvavereewkfdtlcdlydtltitqavifcntkrkvdwltekmrea
nftvssmhgdmpqkeresimkefrsgasrvlistdvwargldvpqvsliinydlpnnrel
yihrigrsgrygrkgvainfvknddirilrdieqyystqidempmnvadli

    Sequence, based on observed residues (ATOM records):
    >2xb2X (X:)
dmtkvefetseevdvtptfdtmglredllrgiyaygfekpsaiqqraikqiikgrdviaq
sqsgtgktatfsisvlqcldiqvretqalilaptrelavqiqkgllalgdymnvqchaci
ggtnvgedirkldygqhvvagtpgrvfdmirrrslrtraikmlvldeademlnkgfkeqi
ydvyrylppatqvvlisatlpheilemtnkfmtdpirilvkrdeltlegikqffvavere
ewkfdtlcdlydtltitqavifcntkrkvdwltekmreanftvssmhgdmpqkeresimk
efrsgasrvlistdvwargldvpqvsliinydlpnnrelyihrigrsgrygrkgvainfv
knddirilrdieqyystqidempmnvadli

  • Chain 'Y':
    Sequence, based on SEQRES records:
    >2xb2Y (Y:)
mesdfylryyvghkgkfgheflefefrpdgklryannsnykndvmirkeayvhksvmeel
kriiddseitkeddalwpppdrvgrqeleivigdehisfttskigslidvnqskdpeglr
vfyylvqdlkclvfsliglhfkikpi

    Sequence, based on observed residues (ATOM records):
    >2xb2Y (Y:)
dfylryyvghkgkfgheflefefrpdgklryannsnykndvmirkeayvhksvmeelkri
iddseitkeddalwpppdrvgrqeleivigdehisfttskigslidvnqskdpeglrvfy
ylvqdlkclvfsliglhfkikpi

  • Chain 'Z':
    Sequence, based on SEQRES records:
    >2xb2Z (Z:)
pqrsvegwilfvtgvheeateedihdkfaeygeiknihlnldrrtgylkgytlveyetyk
eaqaameglngqdlmgqpisvdwcfvrgpp

    Sequence, based on observed residues (ATOM records):
    >2xb2Z (Z:)
pqrsvegwilfvtgvheeateedihdkfaeygeiknihlnldrrtgylkgytlveyetyk
eaqaameglngqdlmgqpisvdwcfvrgp