PDB entry 2xah

View 2xah on RCSB PDB site
Description: crystal structure of lsd1-corest in complex with (+)-trans-2-phenylcyclopropyl-1-amine
Class: transcription
Keywords: amine oxidase, chromatin regulator, histone inhibitor binding, methylation, nucleosome core, oxidoreductase, oxidoreductase-repressor complex, chromatin remodelling, transcription
Deposited on 2010-03-31, released 2010-05-05
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-10-12, with a file datestamp of 2011-10-07.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.20889
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2xaha1, d2xaha2, d2xaha3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2xahb1, d2xahb2
  • Heterogens: FAD, 3PL

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2xahA (A:)
    mlsgkkaaaaaaaaaaaatgteagpgtaggsengsevaaqpaglsgpaevgpgavgertp
    rkkepprasppgglaeppgsagpqagptvvpgsatpmetgiaetpegrrtsrrkrakvey
    remdeslanlsedeyyseeernakaekekklpppppqappeeenesepeepsgvegaafq
    srlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqltfeatlqqlea
    pynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsglaaarqlqsf
    gmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvnmelakikqkc
    plyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgqalevviqlqe
    khvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkpprditaeflv
    kskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqildwhfanlefan
    atplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntavrqvrytasgc
    eviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsavqrmgfgnln
    kvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvageaagimenisd
    dvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssgndydlmaqpi
    tpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqflgamytlprqa
    tpgvpaqqspsm
    

    Sequence, based on observed residues (ATOM records): (download)
    >2xahA (A:)
    psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
    featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
    laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
    melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
    alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
    prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
    whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
    rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
    vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
    aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
    ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
    gamytl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2xahB (B:)
    mvekgpevsgkrrgrnnaaasasaaaasaaasaacaspaataasgaaassasaaaasaaa
    apnngqnkslaaaapngnsssnsweegssgsssdeehggggmrvgpqyqavvpdfdpakl
    arrsqerdnlgmlvwspnqnlseakldeyiaiakekhgynmeqalgmlfwhkhnieksla
    dlpnftpfpdewtvedkvlfeqafsfhgktfhriqqmlpdksiaslvkfyyswkktrtkt
    svmdrharkqkrereesedeleeangnnpidievdqnkeskkevpptetvpqvkkekhst
    qaknrakrkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalk
    ekldggiepyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknf
    fvnyrrrfnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryas
    as
    

    Sequence, based on observed residues (ATOM records): (download)
    >2xahB (B:)
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweae