PDB entry 2xaf

View 2xaf on RCSB PDB site
Description: crystal structure of lsd1-corest in complex with para-bromo-(+)-cis-2-phenylcyclopropyl-1-amine
Class: transcription
Keywords: amine oxidase, chromatin regulator, histone inhibitor binding, methylation, nucleosome core, oxidoreductase, oxidoreductase-repressor complex, chromatin remodelling, transcription
Deposited on 2010-03-31, released 2010-05-05
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-10-12, with a file datestamp of 2011-10-07.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: 0.20251
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2xafa1, d2xafa2, d2xafa3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2xafb1, d2xafb2
  • Heterogens: FAD, TCF

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xafA (A:)
mlsgkkaaaaaaaaaaaatgteagpgtaggsengsevaaqpaglsgpaevgpgavgertp
rkkepprasppgglaeppgsagpqagptvvpgsatpmetgiaetpegrrtsrrkrakvey
remdeslanlsedeyyseeernakaekekklpppppqappeeenesepeepsgvegaafq
srlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqltfeatlqqlea
pynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsglaaarqlqsf
gmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvnmelakikqkc
plyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgqalevviqlqe
khvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkpprditaeflv
kskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqildwhfanlefan
atplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntavrqvrytasgc
eviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsavqrmgfgnln
kvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvageaagimenisd
dvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssgndydlmaqpi
tpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqflgamytlprqa
tpgvpaqqspsm

    Sequence, based on observed residues (ATOM records): (download) 
    >2xafA (A:)
psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
gamytl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xafB (B:)
mvekgpevsgkrrgrnnaaasasaaaasaaasaacaspaataasgaaassasaaaasaaa
apnngqnkslaaaapngnsssnsweegssgsssdeehggggmrvgpqyqavvpdfdpakl
arrsqerdnlgmlvwspnqnlseakldeyiaiakekhgynmeqalgmlfwhkhnieksla
dlpnftpfpdewtvedkvlfeqafsfhgktfhriqqmlpdksiaslvkfyyswkktrtkt
svmdrharkqkrereesedeleeangnnpidievdqnkeskkevpptetvpqvkkekhst
qaknrakrkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalk
ekldggiepyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknf
fvnyrrrfnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryas
as

    Sequence, based on observed residues (ATOM records): (download) 
    >2xafB (B:)
rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
fnidevlqeweae