PDB entry 2xa4

View 2xa4 on RCSB PDB site
Description: Inhibitors of Jak2 Kinase domain
Class: transferase
Keywords: kinase, membrane, transferase, ATP-binding, proto-oncogene, phosphoprotein
Deposited on 2010-03-26, released 2010-12-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (108)
      • engineered mutation (110)
    Domains in SCOPe 2.08: d2xa4a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (108)
      • engineered mutation (110)
    Domains in SCOPe 2.08: d2xa4b_
  • Heterogens: AZ5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2xa4A (A:)
    afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
    fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqahaeridhikll
    qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
    espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
    vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag
    

    Sequence, based on observed residues (ATOM records): (download)
    >2xa4A (A:)
    qfeerhlkflqqlgkfgsvemcrydplqdntgevvavkklqhsteehlrdfereieilks
    lqhdnivkykgvcysnlklimeylpygslrdylqahaeridhikllqytsqickgmeylg
    tkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvespifwyapeslteskfs
    vasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknngrlprpd
    gcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2xa4B (B:)
    afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
    fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqahaeridhikll
    qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
    espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
    vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag
    

    Sequence, based on observed residues (ATOM records): (download)
    >2xa4B (B:)
    qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhlrdfereieilkslqh
    dnivkykgvcnlklimeylpygslrdylqahaeridhikllqytsqickgmeylgtkryi
    hrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkegespifwyapeslteskfsva
    sdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknngrlprpdgc
    pdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma