PDB entry 2x74

View 2x74 on RCSB PDB site
Description: Human foamy virus integrase - catalytic core.
Deposited on 2010-02-23, released 2010-08-11
The last revision was dated 2012-04-18, with a file datestamp of 2012-04-13.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: 0.23633
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: HUMAN SPUMARETROVIRUS [TaxId:11963]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14350
      • engineered mutation (17)
      • conflict (70)
      • engineered mutation (117)
      • engineered mutation (143)
  • Chain 'B':
    Compound: integrase
    Species: HUMAN SPUMARETROVIRUS [TaxId:11963]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14350
      • engineered mutation (17)
      • conflict (70)
      • engineered mutation (117)
      • engineered mutation (143)
  • Chain 'C':
    Compound: integrase
    Species: HUMAN SPUMARETROVIRUS [TaxId:11963]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14350
      • engineered mutation (17)
      • conflict (70)
      • engineered mutation (117)
      • engineered mutation (143)
  • Chain 'D':
    Compound: integrase
    Species: HUMAN SPUMARETROVIRUS [TaxId:11963]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14350
      • engineered mutation (17)
      • conflict (70)
      • engineered mutation (117)
      • engineered mutation (143)
  • Chain 'E':
    Compound: integrase
    Species: HUMAN SPUMARETROVIRUS [TaxId:11963]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14350
      • engineered mutation (17)
      • conflict (70)
      • engineered mutation (117)
      • engineered mutation (143)
  • Chain 'F':
    Compound: integrase
    Species: HUMAN SPUMARETROVIRUS [TaxId:11963]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14350
      • engineered mutation (17)
      • conflict (70)
      • engineered mutation (117)
      • engineered mutation (143)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2x74A (A:)
gpilrpdrpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvks
lnvltsiaiprvihsdqgaaftsstfaewakergihlefstpyhpqsgskverknsdmkr
lltkllvgrptkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltre
eelsllqeirtslyhpstpp

    Sequence, based on observed residues (ATOM records):
    >2x74A (A:)
rpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvkslnvltsi
aiprvihsdqgaaftsstfaewakergihlefstpyhpqskverknsdmkrlltkllvgr
ptkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltreeelsllqei
rtslyhp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2x74B (B:)
gpilrpdrpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvks
lnvltsiaiprvihsdqgaaftsstfaewakergihlefstpyhpqsgskverknsdmkr
lltkllvgrptkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltre
eelsllqeirtslyhpstpp

    Sequence, based on observed residues (ATOM records):
    >2x74B (B:)
rpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvkslnvltsi
aiprvihsdqgaaftsstfaewakergihlefstpyhpskverknsdmkrlltkllvgrp
tkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltreeelsllqeir
tslyhp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >2x74C (C:)
gpilrpdrpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvks
lnvltsiaiprvihsdqgaaftsstfaewakergihlefstpyhpqsgskverknsdmkr
lltkllvgrptkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltre
eelsllqeirtslyhpstpp

    Sequence, based on observed residues (ATOM records):
    >2x74C (C:)
rpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvkslnvltsi
aiprvihsdqgaaftsstfaewakergihlefstrknsdmkrlltkllvgrptkwydllp
vvqlamnntyspvlkytphqllfgidsntpfanqdtldltreeelsllqeirtslyhp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2x74D (D:)
gpilrpdrpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvks
lnvltsiaiprvihsdqgaaftsstfaewakergihlefstpyhpqsgskverknsdmkr
lltkllvgrptkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltre
eelsllqeirtslyhpstpp

    Sequence, based on observed residues (ATOM records):
    >2x74D (D:)
rpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvkslnvltsi
aiprvihsdqgaaftsstfaewakergihlefserknsdmkrlltkllvgrptkwydllp
vvqlamnntyspvlkytphqllfgidsntpfanqdtldltreeelsllqeirtslyh

  • Chain 'E':
    Sequence, based on SEQRES records:
    >2x74E (E:)
gpilrpdrpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvks
lnvltsiaiprvihsdqgaaftsstfaewakergihlefstpyhpqsgskverknsdmkr
lltkllvgrptkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltre
eelsllqeirtslyhpstpp

    Sequence, based on observed residues (ATOM records):
    >2x74E (E:)
rpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvkslnvltsi
aiprvihsdqgaaftsstfaewakergihlefstpyhpqkverknsdmkrlltkllvgrp
tkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltreeelsllqeir
tslyhp

  • Chain 'F':
    Sequence, based on SEQRES records:
    >2x74F (F:)
gpilrpdrpqkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvks
lnvltsiaiprvihsdqgaaftsstfaewakergihlefstpyhpqsgskverknsdmkr
lltkllvgrptkwydllpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltre
eelsllqeirtslyhpstpp

    Sequence, based on observed residues (ATOM records):
    >2x74F (F:)
qkpfdkffmdyigplppsqgylyvlvvvdgmtgftwlyptkapstsatvkslnvltsiai
prvihsdqgaaftsstfaewakergihlefstpyhverknsdmkrlltkllvgrptkwyd
llpvvqlamnntyspvlkytphqllfgidsntpfanqdtldltreeelsllqeirtslyh