PDB entry 2x39

View 2x39 on RCSB PDB site
Description: structure of 4-amino-n-(4-chlorobenzyl)-1-(7h-pyrrolo(2,3-d) pyrimidin-4-yl)piperidine-4-carboxamide bound to pkb
Class: transferase
Keywords: serine/threonine-protein kinase, nucleotide-binding, wnt signaling pathway, kinase, transferase, phosphoprotein
Deposited on 2010-01-22, released 2010-02-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-09-21, with a file datestamp of 2011-09-16.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: 0.169
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: rac-beta serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 2X39 (Start-341)
    • Uniprot P31751 (5-End)
    Domains in SCOPe 2.05: d2x39a_
  • Chain 'C':
    Compound: Glycogen synthase kinase-3 beta
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
  • Heterogens: X39, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2x39A (A:)
    gamdpkvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvte
    srvlqntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeiv
    saleylhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylape
    vledndygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksl
    lagllkkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfd
    deftaqsititppdrydslglleldqreeqemfedfdyiadw
    

    Sequence, based on observed residues (ATOM records): (download)
    >2x39A (A:)
    kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
    ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
    lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
    dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
    kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
    qsitqemfedfdyiadw
    

  • Chain 'C':
    No sequence available.