PDB entry 2x37

View 2x37 on RCSB PDB site
Description: structure of 4-(4-tert-butylbenzyl)-1-(7h-pyrrolo(2,3-d) pyrimidin-4-yl)piperidin-4-amine bound to pkb
Deposited on 2010-01-22, released 2010-02-23
The last revision was dated 2010-06-16, with a file datestamp of 2010-06-11.
Experiment type: XRAY
Resolution: 2.72 Å
R-factor: 0.2393
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: rac-beta serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X37 (Start-341)
    • Uniprot P31751 (5-End)
  • Chain 'C':
    Compound: Glycogen synthase kinase-3 beta
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: X37, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2x37A (A:)
gamdpkvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvte
srvlqntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeiv
saleylhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylape
vledndygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksl
lagllkkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfd
deftaqsititppdrydslglleldqreeqemfedfdyiadw

    Sequence, based on observed residues (ATOM records):
    >2x37A (A:)
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsitqemfedfdyiadw

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >2x37C (C:)
grprttsfae