PDB entry 2x2m

View 2x2m on RCSB PDB site
Description: Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor
Class: transferase
Keywords: hirschsprung disease, gdnf receptor, transmembrane, proto-oncogene, phosphoprotein, disease mutation, phosphotransferase, ret, kinase, membrane, transferase
Deposited on 2010-01-13, released 2010-02-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X2M (0-4)
    • Uniprot P07949 (5-313)
    Domains in SCOPe 2.08: d2x2ma1, d2x2ma2
  • Chain 'B':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X2M (0-4)
    • Uniprot P07949 (5-End)
    Domains in SCOPe 2.08: d2x2mb1, d2x2mb2
  • Heterogens: FMT, X2M, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2x2mA (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2x2mA (A:)
gplslsvdafkildpkwefprknlvlgktlgefgkvvkatafhlkgragyttvavkmlke
naspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresral
tmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeedsyv
krsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnllkt
ghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkrr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2x2mB (B:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2x2mB (B:)
gplslsvdafkipkwefprknlvlgktlgekvvkatafhlkgragyttvavkmlkenasp
selrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresaltmgdl
isfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeedsyvkrsqg
ripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnllktghrme
rpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvk