PDB entry 2x2m
View 2x2m on RCSB PDB site
Description: Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor
Class: transferase
Keywords: hirschsprung disease, gdnf receptor, transmembrane, proto-oncogene, phosphoprotein, disease mutation, phosphotransferase, ret, kinase, membrane, transferase
Deposited on
2010-01-13, released
2010-02-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-08, with a file datestamp of
2019-05-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: proto-oncogene tyrosine-protein kinase receptor ret
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2X2M (0-4)
- Uniprot P07949 (5-313)
Domains in SCOPe 2.08: d2x2ma1, d2x2ma2 - Chain 'B':
Compound: proto-oncogene tyrosine-protein kinase receptor ret
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2X2M (0-4)
- Uniprot P07949 (5-End)
Domains in SCOPe 2.08: d2x2mb1, d2x2mb2 - Heterogens: FMT, X2M, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2x2mA (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr
Sequence, based on observed residues (ATOM records): (download)
>2x2mA (A:)
gplslsvdafkildpkwefprknlvlgktlgefgkvvkatafhlkgragyttvavkmlke
naspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresral
tmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeedsyv
krsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnllkt
ghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkrr
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2x2mB (B:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr
Sequence, based on observed residues (ATOM records): (download)
>2x2mB (B:)
gplslsvdafkipkwefprknlvlgktlgekvvkatafhlkgragyttvavkmlkenasp
selrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresaltmgdl
isfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeedsyvkrsqg
ripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnllktghrme
rpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvk