PDB entry 2x2k

View 2x2k on RCSB PDB site
Description: crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor
Class: transferase
Keywords: tyrosine kinase, hirschsprung disease, tyrosine-protein kinase, proto-oncogene, phosphoprotein, transferase, phosphotransferase
Deposited on 2010-01-13, released 2010-02-09
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-03-02, with a file datestamp of 2010-02-26.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.194
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X2K (0-4)
    • Uniprot P07949 (5-313)
    Domains in SCOPe 2.01: d2x2ka_
  • Heterogens: FMT, X2K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2x2kA (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2x2kA (A:)
gplslsvdafkipkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlke
naspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrkv
raltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeed
syvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnl
lktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkrr