PDB entry 2x1u

View 2x1u on RCSB PDB site
Description: crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase
Class: isomerase
Keywords: gluconeogenesis, lipid synthesis, fatty acid biosynthesis, tim barrel, peroxisome, glycolysis, isomerase, glycosome
Deposited on 2010-01-04, released 2010-01-26
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-07-28, with a file datestamp of 2010-07-23.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: 0.185
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Triosephosphate isomerase, glycosomal
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04789 (225-237)
      • engineered mutation (65-69)
      • engineered mutation (71-72)
      • engineered mutation (90)
      • engineered mutation (223)
    Domains in SCOPe 2.01: d2x1ua_
  • Chain 'B':
    Compound: Triosephosphate isomerase, glycosomal
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04789 (225-237)
      • engineered mutation (12)
      • engineered mutation (15-16)
      • engineered mutation (65-69)
      • engineered mutation (71-72)
      • engineered mutation (90)
      • engineered mutation (223)
    Domains in SCOPe 2.01: d2x1ub_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2x1uA (A:)
skpqpiaaanwksgspdslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfvi
aaqnagnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacige
tlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvatpqqaqeahal
irswvsskigadvagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq

    Sequence, based on observed residues (ATOM records): (download) 
    >2x1uA (A:)
skpqpiaaanwslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfviaaqnag
nadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacigetlqere
sgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvatpqqaqeahalirswvs
skigadvagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2x1uB (B:)
skpqpiaaanwksgspdslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfvi
aaqnagnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacige
tlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvatpqqaqeahal
irswvsskigadvagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq