PDB entry 2x18

View 2x18 on RCSB PDB site
Description: The crystal structure of the PH domain of human AKT3 protein kinase
Class: transferase
Keywords: kinase, membrane, transferase, ATP-binding
Deposited on 2009-12-22, released 2010-03-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2x18a_
  • Chain 'B':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2x18b_
  • Chain 'C':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X18
    • Uniprot Q9Y243 (Start-118)
    Domains in SCOPe 2.08: d2x18c_
  • Chain 'D':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X18
    • Uniprot Q9Y243 (Start-118)
    Domains in SCOPe 2.08: d2x18d_
  • Chain 'E':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X18
    • Uniprot Q9Y243 (Start-118)
    Domains in SCOPe 2.08: d2x18e_
  • Chain 'F':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2x18f_
  • Chain 'G':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X18
    • Uniprot Q9Y243 (Start-118)
    Domains in SCOPe 2.08: d2x18g_
  • Chain 'H':
    Compound: rac-gamma serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X18
    • Uniprot Q9Y243 (Start-118)
    Domains in SCOPe 2.08: d2x18h_
  • Heterogens: EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2x18A (A:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18A (A:)
vtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlmk
terpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqee

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2x18B (B:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18B (B:)
vtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlmk
terpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeerm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2x18C (C:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18C (C:)
vtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlmk
terpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2x18D (D:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18D (D:)
vtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlmk
terpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2x18E (E:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18E (E:)
dvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlm
kterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2x18F (F:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18F (F:)
dvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlm
kterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqe

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2x18G (G:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18G (G:)
vtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlmk
terpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2x18H (H:)
smsdvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakc
qlmkterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn

    Sequence, based on observed residues (ATOM records): (download) 
    >2x18H (H:)
dvtivkegwvqkrgeyiknwrpryfllktdgsfigykekpqdvdlpyplnnfsvakcqlm
kterpkpntfiirclqwttviertfhvdtpeereewteaiqavadrlqrqeeermn