PDB entry 2x0w
View 2x0w on RCSB PDB site
Description: STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole
Class: cell cycle
Keywords: activator, cell cycle, host-virus interaction, transcription regulation, transcription factor, li-fraumeni syndrome, drug discovery, surface crevice, tumor suppressor, protein stabilization, transcription, cancer, apoptosis
Deposited on
2009-12-17, released
2010-01-26
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-08, with a file datestamp of
2019-05-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.08: d2x0wa_ - Chain 'B':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.08: d2x0wb_ - Heterogens: ZN, X0W, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2x0wA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>2x0wA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhs
vvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvc
acpgrdrrteeenlr
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2x0wB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>2x0wB (B:)
vpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstpppgtr
vramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhsv
vvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvca
cpgrdrrteeenlr