PDB entry 2x0b

View 2x0b on RCSB PDB site
Description: crystal structure of human angiotensinogen complexed with renin
Deposited on 2009-12-08, released 2010-10-20
The last revision was dated 2011-05-11, with a file datestamp of 2011-05-06.
Experiment type: XRAY
Resolution: 4.33 Å
R-factor: 0.31
AEROSPACI score: 0.02 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: angiotensinogen
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01019
      • conflict (46)
  • Chain 'C':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: angiotensinogen
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01019
      • conflict (46)
  • Chain 'E':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: angiotensinogen
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01019
      • conflict (46)
  • Chain 'G':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: angiotensinogen
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01019
      • conflict (46)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2x0bA (A:)
lptdtttfkriflkrmpsireslkergvdmarlgpewsqpmkrltlgnttssviltnymd
tqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdasdsssykhngt
eltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgvvgmgfieqai
grvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpqhyegnfhyinlik
tgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakkrlfdyvv
kcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptgptwalga
tfirkfytefdrrnnrigfalar

    Sequence, based on observed residues (ATOM records):
    >2x0bA (A:)
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsenlggqivlggsdpqhyegnf
hyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakk
rlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptg
ptwalgatfirkfytefdrrnnrigfalar

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2x0bB (B:)
drvyihpfhlvihnestceqlakanagkpkdptfipapiqaktspvnekalqdqlvlvaa
kldtedklraamvgmlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldh
tadrlqailgvpwkdknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvft
apglhlkqpfvqglalytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvd
stlafntyvhfqgkmkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtq
vpftesacllliqphyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlq
dllaqaelpailhtelnlqklsndrirvgevlnsiffeleadereptestqqlnkpevle
vtlnrpflfavydqsatalhflgrvanplsta

    Sequence, based on observed residues (ATOM records):
    >2x0bB (B:)
vyihpfhlvihnestcdptfipapiqaktspvnekalqdqlvlvaakldtedklraamvg
mlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldhtadrlqailgvpwk
dknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvftapglhlkqpfvqgl
alytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvdstlafntyvhfqgk
mkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtqvpftesacllliqp
hyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlqdllaqaelpailht
elnlqklsndrirvgevlnsiffeleadepevlevtlnrpflfavydqsatalhflgrva
npl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >2x0bC (C:)
lptdtttfkriflkrmpsireslkergvdmarlgpewsqpmkrltlgnttssviltnymd
tqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdasdsssykhngt
eltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgvvgmgfieqai
grvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpqhyegnfhyinlik
tgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakkrlfdyvv
kcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptgptwalga
tfirkfytefdrrnnrigfalar

    Sequence, based on observed residues (ATOM records):
    >2x0bC (C:)
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsenlggqivlggsdpqhyegnf
hyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakk
rlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptg
ptwalgatfirkfytefdrrnnrigfalar

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2x0bD (D:)
drvyihpfhlvihnestceqlakanagkpkdptfipapiqaktspvnekalqdqlvlvaa
kldtedklraamvgmlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldh
tadrlqailgvpwkdknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvft
apglhlkqpfvqglalytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvd
stlafntyvhfqgkmkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtq
vpftesacllliqphyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlq
dllaqaelpailhtelnlqklsndrirvgevlnsiffeleadereptestqqlnkpevle
vtlnrpflfavydqsatalhflgrvanplsta

    Sequence, based on observed residues (ATOM records):
    >2x0bD (D:)
vyihpfhlvihnestcdptfipapiqaktspvnekalqdqlvlvaakldtedklraamvg
mlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldhtadrlqailgvpwk
dknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvftapglhlkqpfvqgl
alytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvdstlafntyvhfqgk
mkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtqvpftesacllliqp
hyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlqdllaqaelpailht
elnlqklsndrirvgevlnsiffeleadepevlevtlnrpflfavydqsatalhflgrva
npl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >2x0bE (E:)
lptdtttfkriflkrmpsireslkergvdmarlgpewsqpmkrltlgnttssviltnymd
tqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdasdsssykhngt
eltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgvvgmgfieqai
grvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpqhyegnfhyinlik
tgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakkrlfdyvv
kcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptgptwalga
tfirkfytefdrrnnrigfalar

    Sequence, based on observed residues (ATOM records):
    >2x0bE (E:)
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsenlggqivlggsdpqhyegnf
hyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakk
rlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptg
ptwalgatfirkfytefdrrnnrigfalar

  • Chain 'F':
    Sequence, based on SEQRES records:
    >2x0bF (F:)
drvyihpfhlvihnestceqlakanagkpkdptfipapiqaktspvnekalqdqlvlvaa
kldtedklraamvgmlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldh
tadrlqailgvpwkdknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvft
apglhlkqpfvqglalytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvd
stlafntyvhfqgkmkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtq
vpftesacllliqphyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlq
dllaqaelpailhtelnlqklsndrirvgevlnsiffeleadereptestqqlnkpevle
vtlnrpflfavydqsatalhflgrvanplsta

    Sequence, based on observed residues (ATOM records):
    >2x0bF (F:)
vyihpfhlvihnestcdptfipapiqaktspvnekalqdqlvlvaakldtedklraamvg
mlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldhtadrlqailgvpwk
dknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvftapglhlkqpfvqgl
alytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvdstlafntyvhfqgk
mkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtqvpftesacllliqp
hyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlqdllaqaelpailht
elnlqklsndrirvgevlnsiffeleadepevlevtlnrpflfavydqsatalhflgrva
npl

  • Chain 'G':
    Sequence, based on SEQRES records:
    >2x0bG (G:)
lptdtttfkriflkrmpsireslkergvdmarlgpewsqpmkrltlgnttssviltnymd
tqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdasdsssykhngt
eltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgvvgmgfieqai
grvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpqhyegnfhyinlik
tgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakkrlfdyvv
kcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptgptwalga
tfirkfytefdrrnnrigfalar

    Sequence, based on observed residues (ATOM records):
    >2x0bG (G:)
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsenlggqivlggsdpqhyegnf
hyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakk
rlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptg
ptwalgatfirkfytefdrrnnrigfalar

  • Chain 'H':
    Sequence, based on SEQRES records:
    >2x0bH (H:)
drvyihpfhlvihnestceqlakanagkpkdptfipapiqaktspvnekalqdqlvlvaa
kldtedklraamvgmlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldh
tadrlqailgvpwkdknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvft
apglhlkqpfvqglalytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvd
stlafntyvhfqgkmkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtq
vpftesacllliqphyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlq
dllaqaelpailhtelnlqklsndrirvgevlnsiffeleadereptestqqlnkpevle
vtlnrpflfavydqsatalhflgrvanplsta

    Sequence, based on observed residues (ATOM records):
    >2x0bH (H:)
vyihpfhlvihnestcdptfipapiqaktspvnekalqdqlvlvaakldtedklraamvg
mlanflgfriygmhselwgvvhgatvlsptavfgtlaslylgaldhtadrlqailgvpwk
dknctsrldahkvlsalqavqgllvaqgradsqaqlllstvvgvftapglhlkqpfvqgl
alytpvvlprsldfteldvaaekidrfmqavtgwktgcslmgasvdstlafntyvhfqgk
mkgfsllaepqefwvdnstsvsvpmlsgmgtfqhwsdiqdnfsvtqvpftesacllliqp
hyasdldkvegltfqqnslnwmkklsprtihltmpqlvlqgsydlqdllaqaelpailht
elnlqklsndrirvgevlnsiffeleadepevlevtlnrpflfavydqsatalhflgrva
npl