PDB entry 2x05

View 2x05 on RCSB PDB site
Description: inhibition of the exo-beta-d-glucosaminidase csxa by a glucosamine-configured castanospermine and an amino-australine analogue
Class: hydrolase
Keywords: exo-beta-d-glucosaminidase, glycoside hydrolase, gh2, csxa, hydrolase, glycosidase
Deposited on 2009-12-05, released 2009-12-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-02-02, with a file datestamp of 2010-01-29.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.18723
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: exo-beta-d-glucosaminidase
    Species: AMYCOLATOPSIS ORIENTALIS [TaxId:31958]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X05
      • conflict (749)
    • Uniprot Q56F26
    Domains in SCOPe 2.08: d2x05a1, d2x05a2, d2x05a3, d2x05a4, d2x05a5
  • Chain 'B':
    Compound: exo-beta-d-glucosaminidase
    Species: AMYCOLATOPSIS ORIENTALIS [TaxId:31958]
    Database cross-references and differences (RAF-indexed):
    • PDB 2X05
      • conflict (749)
    • Uniprot Q56F26
    Domains in SCOPe 2.08: d2x05b1, d2x05b2, d2x05b3, d2x05b4, d2x05b5
  • Heterogens: X05, CD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2x05A (A:)
vsfrqkrtripllamtvtalaaavcgvttapaatgaevavplsvgaaagnatpipgyviq
ssaqvsddsavskpgfptsgwypvssrstvyagllqngkyadpfystnmqnvpaaqfsvp
wwyrtdlnvddtssrtyldfsgvlskadvwvngtkvatkdqvngaytrhdlditaqvhtg
vnsvafkvypndpnrdlsmgwidwaqtppdqnmgivrdvlvrrsgavalrsahviqklns
aldhadltvkadvrndsanavqttvagtvagkpisqtvslaakerktvtfplvgldrpnv
wwpagmggqhrydldltasvggtpsdaakskfgvrdvkatlnssggrqysvngkpllirg
ggytpdlflrwnetaaadklkyvlnlglntvrleghiepdeffdiaddlgvltmpgwecc
dkwegqvngeekgepwvesdypiakasmfseaerlrdhpsvisfhigsdfapdrrieqgy
ldamkaadfllpvipaasarpspitgasgmkmngpydyvppvywydksqkdrggawsfns
etsagvdiptmdtlkrmmsaseldtmwknpsakqyhrsssdtfgnlklfgdaltkrygas
anlndfvrkaqlsqyenvraefeshsrnytdstnpstgliywmlnspwtslhwqlfdaym
dqngayygakkaneplhiqyshdnrsvvvinqtsnavsgltattklynldgtekysntkt
glsvgalgakatavtvpavsglsttylaknvltdssgkevsrnvywlstkadtlnwggsd
wyytpqsafadlsglnnlgqsavgatansvagadgtttttvtlkntsggrlpafyvdskv
vdsagkpvlpvewndnavslwpgetttltakyrtadlkgskpsvrisgwntgtqtvpadg
sgpgpsdpvdyqaedativqgavesnhagytgtgfvnydnvagssvewtvtvpsagtydv
vvryangtttsrpldfsvngsisasgvafgstgtwpawttktvrvtlaagvnkikavatt
anggpnvdkitl

    Sequence, based on observed residues (ATOM records): (download) 
    >2x05A (A:)
agnatpipgyviqssaqvsddsavskpgfptsgwypvssrstvyagllqngkyadpfyst
nmqnvpaaqfsvpwwyrtdlnvddtssrtyldfsgvlskadvwvngtkvatkdqvngayt
rhdlditaqvhtgvnsvafkvypndpnrdlsmgwidwaqtppdqnmgivrdvlvrrsgav
alrsahviqklnsaldhadltvkadvrndsanavqttvagtvagkpisqtvslaakerkt
vtfplvgldrpnvwwpagmggqhrydldltasvggtpsdaakskfgvrdvkatlnssggr
qysvngkpllirgggytpdlflrwnetaaadklkyvlnlglntvrleghiepdeffdiad
dlgvltmpgweccdkwegqvngeekgepwvesdypiakasmfseaerlrdhpsvisfhig
sdfapdrrieqgyldamkaadfllpvipaasarpspitgasgmkmngpydyvppvywydk
sqkdrggawsfnsetsagvdiptmdtlkrmmsaseldtmwknpsakqyhrsssdtfgnlk
lfgdaltkrygasanlndfvrkaqlsqyenvraefeshsrnytdstnpstgliywmlnsp
wtslhwqlfdaymdqngayygakkaneplhiqyshdnrsvvvinqtsnavsgltattkly
nldgtekysntktglsvgalgakatavtvpavsglsttylaknvltdssgkevsrnvywl
stkadtlnwggsdwyytpqsafadlsglnnlgqsavgatansvagadgtttttvtlknts
ggrlpafyvdskvvdsagkpvlpvewndnavslwpgetttltakyrtadlkgskpsvris
gwntgtqtvpad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2x05B (B:)
vsfrqkrtripllamtvtalaaavcgvttapaatgaevavplsvgaaagnatpipgyviq
ssaqvsddsavskpgfptsgwypvssrstvyagllqngkyadpfystnmqnvpaaqfsvp
wwyrtdlnvddtssrtyldfsgvlskadvwvngtkvatkdqvngaytrhdlditaqvhtg
vnsvafkvypndpnrdlsmgwidwaqtppdqnmgivrdvlvrrsgavalrsahviqklns
aldhadltvkadvrndsanavqttvagtvagkpisqtvslaakerktvtfplvgldrpnv
wwpagmggqhrydldltasvggtpsdaakskfgvrdvkatlnssggrqysvngkpllirg
ggytpdlflrwnetaaadklkyvlnlglntvrleghiepdeffdiaddlgvltmpgwecc
dkwegqvngeekgepwvesdypiakasmfseaerlrdhpsvisfhigsdfapdrrieqgy
ldamkaadfllpvipaasarpspitgasgmkmngpydyvppvywydksqkdrggawsfns
etsagvdiptmdtlkrmmsaseldtmwknpsakqyhrsssdtfgnlklfgdaltkrygas
anlndfvrkaqlsqyenvraefeshsrnytdstnpstgliywmlnspwtslhwqlfdaym
dqngayygakkaneplhiqyshdnrsvvvinqtsnavsgltattklynldgtekysntkt
glsvgalgakatavtvpavsglsttylaknvltdssgkevsrnvywlstkadtlnwggsd
wyytpqsafadlsglnnlgqsavgatansvagadgtttttvtlkntsggrlpafyvdskv
vdsagkpvlpvewndnavslwpgetttltakyrtadlkgskpsvrisgwntgtqtvpadg
sgpgpsdpvdyqaedativqgavesnhagytgtgfvnydnvagssvewtvtvpsagtydv
vvryangtttsrpldfsvngsisasgvafgstgtwpawttktvrvtlaagvnkikavatt
anggpnvdkitl

    Sequence, based on observed residues (ATOM records): (download) 
    >2x05B (B:)
agnatpipgyviqssaqvsddsavskpgfptsgwypvssrstvyagllqngkyadpfyst
nmqnvpaaqfsvpwwyrtdlnvddtssrtyldfsgvlskadvwvngtkvatkdqvngayt
rhdlditaqvhtgvnsvafkvypndpnrdlsmgwidwaqtppdqnmgivrdvlvrrsgav
alrsahviqklnsaldhadltvkadvrndsanavqttvagtvagkpisqtvslaakerkt
vtfplvgldrpnvwwpagmggqhrydldltasvggtpsdaakskfgvrdvkatlnssggr
qysvngkpllirgggytpdlflrwnetaaadklkyvlnlglntvrleghiepdeffdiad
dlgvltmpgweccdkwegqvngeekgepwvesdypiakasmfseaerlrdhpsvisfhig
sdfapdrrieqgyldamkaadfllpvipaasarpspitgasgmkmngpydyvppvywydk
sqkdrggawsfnsetsagvdiptmdtlkrmmsaseldtmwknpsakqyhrsssdtfgnlk
lfgdaltkrygasanlndfvrkaqlsqyenvraefeshsrnytdstnpstgliywmlnsp
wtslhwqlfdaymdqngayygakkaneplhiqyshdnrsvvvinqtsnavsgltattkly
nldgtekysntktglsvgalgakatavtvpavsglsttylaknvltdssgkevsrnvywl
stkadtlnwggsdwyytpqsafadlsglnnlgqsavgatansvagadgtttttvtlknts
ggrlpafyvdskvvdsagkpvlpvewndnavslwpgetttltakyrtadlkgskpsvris
gwntgtqtvpad