PDB entry 2wzj

View 2wzj on RCSB PDB site
Description: Catalytic and UBA domain of kinase MARK2/(Par-1) K82R, T208E double mutant
Class: transferase
Keywords: uba domain, transferase, serine/threonine-protein kinase, signaling protein, s/t protein kinase, differentiation, developmental protein
Deposited on 2009-11-30, released 2009-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-06, with a file datestamp of 2019-02-01.
Experiment type: XRAY
Resolution: 2.79 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase MARK2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WZJ
      • engineered mutation (44)
      • engineered mutation (170)
    • Uniprot O08679
    Domains in SCOPe 2.08: d2wzja_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase MARK2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WZJ
      • engineered mutation (44)
      • engineered mutation (170)
    • Uniprot O08679
    Domains in SCOPe 2.08: d2wzjb_
  • Chain 'C':
    Compound: Serine/threonine-protein kinase MARK2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WZJ
      • engineered mutation (44)
      • engineered mutation (170)
    • Uniprot O08679
    Domains in SCOPe 2.08: d2wzjc_
  • Chain 'D':
    Compound: Serine/threonine-protein kinase MARK2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WZJ
      • engineered mutation (44)
      • engineered mutation (170)
    • Uniprot O08679
    Domains in SCOPe 2.08: d2wzjd_
  • Chain 'E':
    Compound: Serine/threonine-protein kinase MARK2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WZJ
      • engineered mutation (44)
      • engineered mutation (170)
    • Uniprot O08679
    Domains in SCOPe 2.08: d2wzje_
  • Chain 'F':
    Compound: Serine/threonine-protein kinase MARK2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WZJ
      • engineered mutation (44)
      • engineered mutation (170)
    • Uniprot O08679
    Domains in SCOPe 2.08: d2wzjf_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2wzjA (A:)
    gnsatsadeqphignyrllktigkgnfakvklarhiltgkevavriidktqlnssslqkl
    frevrimkvlnhpnivklfevietektlylvmeyasggevfdylvahgrmkekearakfr
    qivsavqychqkfivhrdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaa
    pelfqgkkydgpevdvwslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdc
    enllkkflilnpskrgtleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgy
    treeiqdslvgqrynevmatylllgyk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wzjA (A:)
    hignyrllktiakvklarhiltgkevavriidktqlnssslqklfrevrimkvlnhpniv
    klfevietektlylvmeyasggevfdylvahgrmkekearakfrqivsavqychqkfivh
    rdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaapelfqgkkydgpevdv
    wslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdcenllkkflilnpskrg
    tleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgytreeiqdslvgqryne
    vmatylllgy
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2wzjB (B:)
    gnsatsadeqphignyrllktigkgnfakvklarhiltgkevavriidktqlnssslqkl
    frevrimkvlnhpnivklfevietektlylvmeyasggevfdylvahgrmkekearakfr
    qivsavqychqkfivhrdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaa
    pelfqgkkydgpevdvwslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdc
    enllkkflilnpskrgtleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgy
    treeiqdslvgqrynevmatylllgyk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wzjB (B:)
    hignyrllktiakvklarhiltgkevavriidktqlnssslqklfrevrimkvlnhpniv
    klfevietektlylvmeyasggevfdylvahgrmkekearakfrqivsavqychqkfivh
    rdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaapelfqgkkydgpevdv
    wslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdcenllkkflilnpskrg
    tleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgytreeiqdslvgqryne
    vmatylllgy
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2wzjC (C:)
    gnsatsadeqphignyrllktigkgnfakvklarhiltgkevavriidktqlnssslqkl
    frevrimkvlnhpnivklfevietektlylvmeyasggevfdylvahgrmkekearakfr
    qivsavqychqkfivhrdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaa
    pelfqgkkydgpevdvwslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdc
    enllkkflilnpskrgtleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgy
    treeiqdslvgqrynevmatylllgyk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wzjC (C:)
    hignyrllktiakvklarhiltgkevavriidktqlnssslqklfrevrimkvlnhpniv
    klfevietektlylvmeyasggevfdylvahgrmkekearakfrqivsavqychqkfivh
    rdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaapelfqgkkydgpevdv
    wslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdcenllkkflilnpskrg
    tleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgytreeiqdslvgqryne
    vmatylllgy
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2wzjD (D:)
    gnsatsadeqphignyrllktigkgnfakvklarhiltgkevavriidktqlnssslqkl
    frevrimkvlnhpnivklfevietektlylvmeyasggevfdylvahgrmkekearakfr
    qivsavqychqkfivhrdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaa
    pelfqgkkydgpevdvwslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdc
    enllkkflilnpskrgtleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgy
    treeiqdslvgqrynevmatylllgyk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wzjD (D:)
    eqphignyrllktiakvklarhiltgkevavriidktqlnssslqklfrevrimkvlnhp
    nivklfevietektlylvmeyasggevfdylvahgrmkekearakfrqivsavqychqkf
    ivhrdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaapelfqgkkydgpe
    vdvwslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdcenllkkflilnps
    krgtleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgytreeiqdslvgqr
    ynevmatylllgy
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >2wzjE (E:)
    gnsatsadeqphignyrllktigkgnfakvklarhiltgkevavriidktqlnssslqkl
    frevrimkvlnhpnivklfevietektlylvmeyasggevfdylvahgrmkekearakfr
    qivsavqychqkfivhrdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaa
    pelfqgkkydgpevdvwslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdc
    enllkkflilnpskrgtleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgy
    treeiqdslvgqrynevmatylllgyk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wzjE (E:)
    hignyrllktiakvklarhiltgkevavriidktqlnssslqklfrevrimkvlnhpniv
    klfevietektlylvmeyasggevfdylvahgrmkekearakfrqivsavqychqkfivh
    rdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaapelfqgkkydgpevdv
    wslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdcenllkkflilnpskrg
    tleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgytreeiqdslvgqryne
    vmatylllgy
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >2wzjF (F:)
    gnsatsadeqphignyrllktigkgnfakvklarhiltgkevavriidktqlnssslqkl
    frevrimkvlnhpnivklfevietektlylvmeyasggevfdylvahgrmkekearakfr
    qivsavqychqkfivhrdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaa
    pelfqgkkydgpevdvwslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdc
    enllkkflilnpskrgtleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgy
    treeiqdslvgqrynevmatylllgyk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wzjF (F:)
    hignyrllktiakvklarhiltgkevavriidktqlnssslqklfrevrimkvlnhpniv
    klfevietektlylvmeyasggevfdylvahgrmkekearakfrqivsavqychqkfivh
    rdlkaenllldadmnikiadfgfsneftfgnkldefcgsppyaapelfqgkkydgpevdv
    wslgvilytlvsgslpfdgqnlkelrervlrgkyripfymstdcenllkkflilnpskrg
    tleqimkdrwmnvgheddelkpyveplpdykdprrtelmvsmgytreeiqdslvgqryne
    vmatylllgy