PDB entry 2wyg

View 2wyg on RCSB PDB site
Description: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with monoaryl p4 motifs
Class: blood clotting
Keywords: blood clotting, serine protease, egf-like domain, blood coagulation, hydrolase, hydroxylation, zymogen
Deposited on 2009-11-16, released 2010-12-01
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-12-01, with a file datestamp of 2010-11-26.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: 0.19759
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2wyga_
  • Chain 'B':
    Compound: factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 461, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2wygA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    kshapevitssplk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wygA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    avhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlmtqktgi
    vsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedacqgdsg
    gphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
    

  • Chain 'B':
    No sequence available.