PDB entry 2wx2

View 2wx2 on RCSB PDB site
Description: x-ray structure of cyp51 from the human pathogen trypanosoma cruzi in complex with fluconazole
Class: oxidoreductase
Keywords: p450, heme, iron, metal-binding, methyltransferase, ergosterol biosynthesis, oxidoreductase
Deposited on 2009-10-31, released 2009-11-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-04-11, with a file datestamp of 2012-04-06.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: 0.19677
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lanosterol 14-alpha-demethylase
    Species: Trypanosoma cruzi [TaxId:5693]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wx2a_
  • Chain 'B':
    Compound: lanosterol 14-alpha-demethylase
    Species: Trypanosoma cruzi [TaxId:5693]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WX2 (467-End)
    • Uniprot Q7Z1V1 (Start-466)
    Domains in SCOPe 2.08: d2wx2b1, d2wx2b2
  • Heterogens: HEM, TPF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wx2A (A:)
makkkkkksfnttrptdppvypvtvpflghivqfgknplefmqrckrdlksgvftisigg
qrvtivgdphehsrffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeel
tiakfqnfvpaiqhevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlna
rhfaqllskmesslipaavfmpwllrlplpqsarcrearaelqkilgeiivarekeeask
dnntsdllggllkavyrdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkk
wldklhkeidefpaqlnydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvv
pkgdiiacspllshhdeeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvkt
ilatafreydfqllrdevpdpdyhtmvvgptlnqclvkytrkkklpshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wx2A (A:)
ttrptdppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphe
hsrffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpa
iqhevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskme
sslipaavfmpwllrlplprcrearaelqkilgeiivarekesdllggllkavyrdgtrm
slhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnvm
dempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafpn
prlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdpd
yhtmvvgptlnqclvkytrkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wx2B (B:)
makkkkkksfnttrptdppvypvtvpflghivqfgknplefmqrckrdlksgvftisigg
qrvtivgdphehsrffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeel
tiakfqnfvpaiqhevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlna
rhfaqllskmesslipaavfmpwllrlplpqsarcrearaelqkilgeiivarekeeask
dnntsdllggllkavyrdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkk
wldklhkeidefpaqlnydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvv
pkgdiiacspllshhdeeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvkt
ilatafreydfqllrdevpdpdyhtmvvgptlnqclvkytrkkklpshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wx2B (B:)
rptdppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehs
rffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiq
hevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllslipaa
vfmpwllrlplpqsarcrearaelqkilgeiivareksdllggllkavyrdgtrmslhev
cgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnvmdempf
aercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafpnprlwd
perdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdpdyhtmv
vgptlnqclvkytrkkklpshhhh