PDB entry 2wv8

View 2wv8 on RCSB PDB site
Description: Complex of human dihydroorotate dehydrogenase with the inhibitor 221290
Class: oxidoreductase
Keywords: flavoprotein, transmembrane, mitochondrion inner membrane, oxidoreductase, transit peptide, enzyme inhibition, pyrimidine biosynthesis, structure-based drug design, inflamation
Deposited on 2009-10-15, released 2010-08-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-17, with a file datestamp of 2018-01-12.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wv8a_
  • Heterogens: FMN, ORO, VGN, DDQ, ACT, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2wv8A (A:)
tgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnp
vgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfns
hglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvv
nvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasv
vkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpii
gvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaig
adhrr