PDB entry 2wv5

View 2wv5 on RCSB PDB site
Description: crystal structure of foot-and-mouth disease virus 3c protease in complex with a decameric peptide corresponding to the vp1-2a cleavage junction with a gln to glu substitution at p1
Class: hydrolase/peptide
Keywords: 3C PROTEASE, HYDROLASE, VIRAL PROTEIN, HYDROLASE PEPTIDE COMPLEX, HYDROLASE-PEPTIDE complex
Deposited on 2009-10-13, released 2009-10-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2010-02-09, with a file datestamp of 2010-02-05.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.236
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: picornain 3c
    Species: FOOT-AND-MOUTH DISEASE VIRUS [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • see remark 999 (22)
      • see remark 999 (88)
      • engineered mutation (95)
      • engineered mutation (142)
      • engineered mutation (163)
    • Uniprot P03306
    Domains in SCOPe 2.05: d2wv5a_
  • Chain 'B':
    Compound: picornain 3c
    Species: FOOT-AND-MOUTH DISEASE VIRUS [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • see remark 999 (22)
      • see remark 999 (88)
      • engineered mutation (95)
      • engineered mutation (142)
      • engineered mutation (163)
    • Uniprot P03306
    Domains in SCOPe 2.05: d2wv5b_
  • Chain 'C':
    Compound: picornain 3c
    Species: FOOT-AND-MOUTH DISEASE VIRUS [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • see remark 999 (22)
      • see remark 999 (88)
      • engineered mutation (95)
      • engineered mutation (142)
      • engineered mutation (163)
    • Uniprot P03306
    Domains in SCOPe 2.05: d2wv5c_
  • Chain 'D':
    Compound: picornain 3c
    Species: FOOT-AND-MOUTH DISEASE VIRUS [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • see remark 999 (22)
      • see remark 999 (88)
      • engineered mutation (95)
      • engineered mutation (142)
      • engineered mutation (163)
    • Uniprot P03306
    Domains in SCOPe 2.05: d2wv5d_
  • Chain 'E':
    Compound: foot and mouth disease virus (serotype a) variant vp1 capsid protein
    Species: FOOT-AND-MOUTH DISEASE VIRUS, synthetic [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • engineered mutation (4)
    • Uniprot Q65050 (0-End)
  • Chain 'F':
    Compound: foot and mouth disease virus (serotype a) variant vp1 capsid protein
    Species: FOOT-AND-MOUTH DISEASE VIRUS, synthetic [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • engineered mutation (4)
    • Uniprot Q65050 (0-End)
  • Chain 'G':
    Compound: foot and mouth disease virus (serotype a) variant vp1 capsid protein
    Species: FOOT-AND-MOUTH DISEASE VIRUS, synthetic [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • engineered mutation (4)
    • Uniprot Q65050 (0-End)
  • Chain 'H':
    Compound: foot and mouth disease virus (serotype a) variant vp1 capsid protein
    Species: FOOT-AND-MOUTH DISEASE VIRUS, synthetic [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV5
      • engineered mutation (4)
    • Uniprot Q65050 (0-End)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wv5A (A:)
gsgapptdlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldg
ramtdsdyrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvv
nnadvgrlifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivg
thsaggngvgycscvsrsmlqkmkahvdpephhe

    Sequence, based on observed residues (ATOM records): (download) 
    >2wv5A (A:)
dlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldgramtdsd
yrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvvnnadvgr
lifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivgthsaggn
gvgycscvsrsmlqkmkahv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wv5B (B:)
gsgapptdlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldg
ramtdsdyrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvv
nnadvgrlifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivg
thsaggngvgycscvsrsmlqkmkahvdpephhe

    Sequence, based on observed residues (ATOM records): (download) 
    >2wv5B (B:)
dlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldgramtdsd
yrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvvnnadvgr
lifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivgthsaggn
gvgycscvsrsmlqkmkahv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2wv5C (C:)
gsgapptdlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldg
ramtdsdyrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvv
nnadvgrlifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivg
thsaggngvgycscvsrsmlqkmkahvdpephhe

    Sequence, based on observed residues (ATOM records): (download) 
    >2wv5C (C:)
dlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldgramtdsd
yrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvvnnadvgr
lifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivgthsaggn
gvgycscvsrsmlqkmkahv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2wv5D (D:)
gsgapptdlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldg
ramtdsdyrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvv
nnadvgrlifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivg
thsaggngvgycscvsrsmlqkmkahvdpephhe

    Sequence, based on observed residues (ATOM records): (download) 
    >2wv5D (D:)
dlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldgramtdsd
yrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvvnnadvgr
lifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivgthsaggn
gvgycscvsrsmlqkmkahv

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.