PDB entry 2wv4

View 2wv4 on RCSB PDB site
Description: crystal structure of foot-and-mouth disease virus 3c protease in complex with a decameric peptide corresponding to the vp1-2a cleavage junction
Class: hydrolase/peptide
Keywords: HYDROLASE PEPTIDE COMPLEX, 3C PROTEASE, HYDROLASE, VIRAL PROTEIN, HYDROLASE-PEPTIDE complex
Deposited on 2009-10-13, released 2009-10-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-02-09, with a file datestamp of 2010-02-05.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.212
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: picornain 3c
    Species: FOOT-AND-MOUTH DISEASE VIRUS [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV4
      • see remark 999 (22)
      • see remark 999 (88)
      • engineered mutation (95)
      • engineered mutation (142)
      • engineered mutation (163)
    • Uniprot P03306
    Domains in SCOPe 2.08: d2wv4a_
  • Chain 'B':
    Compound: picornain 3c
    Species: FOOT-AND-MOUTH DISEASE VIRUS [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV4
      • see remark 999 (22)
      • see remark 999 (88)
      • engineered mutation (95)
      • engineered mutation (142)
      • engineered mutation (163)
    • Uniprot P03306
    Domains in SCOPe 2.08: d2wv4b_
  • Chain 'C':
    Compound: foot and mouth disease virus (serotype a) variant vp1 capsid protein
    Species: FOOT-AND-MOUTH DISEASE VIRUS, synthetic [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV4
    • Uniprot Q65050 (0-End)
  • Chain 'D':
    Compound: foot and mouth disease virus (serotype a) variant vp1 capsid protein
    Species: FOOT-AND-MOUTH DISEASE VIRUS, synthetic [TaxId:12112]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WV4
    • Uniprot Q65050 (0-End)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wv4A (A:)
gsgapptdlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldg
ramtdsdyrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvv
nnadvgrlifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivg
thsaggngvgycscvsrsmlqkmkahvdpephhe

    Sequence, based on observed residues (ATOM records): (download) 
    >2wv4A (A:)
dlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldgramtdsd
yrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvvnnadvgr
lifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivgthsaggn
gvgycscvsrsmlqkmkahvd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wv4B (B:)
gsgapptdlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldg
ramtdsdyrvfefeikvkgqdmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvv
nnadvgrlifsgealtykdivvlmdgdtmpglfaykaatragyaggavlakdgadtfivg
thsaggngvgycscvsrsmlqkmkahvdpephhe

    Sequence, based on observed residues (ATOM records): (download) 
    >2wv4B (B:)
tdlqkmvmgntkpvelildgktvaiccatgvfgtaylvprhlfaekydkimldgramtds
dyrvfefeikvkmlsdaalmvlhrgnkvrditkhfrdtarmkkgtpvvgvvnnadvgrli
fsgealtykdivvlmdgdtmpglfaykaatragyaggavlaadtfivgthsaggngvgyc
scvsrsmlqkmkahvd

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.