PDB entry 2wv2

View 2wv2 on RCSB PDB site
Description: X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole
Class: oxidoreductase
Keywords: oxidoreductase, methyltransferase, p450, iron, cyp51, metal-binding, ergosterol biosynthesis
Deposited on 2009-10-12, released 2009-11-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-05-30, with a file datestamp of 2012-05-25.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.213
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lanosterol 14-alpha-demethylase
    Species: Trypanosoma brucei [TaxId:5691]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wv2a_
  • Heterogens: TPF, HEM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wv2A (A:)
makkkkkksfnvtrptdppvypvtvpilghiiqfgksplgfmqeckrqlksgiftinivg
krvtivgdphehsrfflprnevlsprevysfmvpvfgegvayaapyprmreqlnflaeel
tiakfqnfvpaiqhevrkfmaanwdkdegeinlledcstmiintacqclfgedlrkrlda
rrfaqllakmesslipaavflpillklplpqsarcheartelqkilseiiiarkeeevnk
dsstsdllsgllsavyrdgtpmslhevcgmivaamfagqhtssitttwsmlhlmhpanvk
hlealrkeieefpaqlnynnvmdempfaercaresirrdppllmlmrkvmadvkvgsyvv
pkgdiiacspllshhdeeafpeprrwdperdekvegafigfgagvhkcigqkfgllqvkt
ilatafrsydfqllrdevpdpdyhtmvvgptasqcrvkyirrkaaaahhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wv2A (A:)
tdppvypvtvpilghiiqfgksplgfmqeckrqlksgiftinivgkrvtivgdphehsrf
flprnevlsprevysfmvpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhe
vrkfmaanwdkdegeinlledcstmiintacqclfgedlrkrldarrfaqllakmessli
paavflpillklplpqsarcheartelqkilseiiiarkeeevtsdllsgllsavyrdgt
pmslhevcgmivaamfagqhtssitttwsmlhlmhpanvkhlealrkeieefpaqlnynn
vmdempfaercaresirrdppllmlmrkvmadvkvgsyvvpkgdiiacspllshhdeeaf
peprrwdperdekvegafigfgagvhkcigqkfgllqvktilatafrsydfqllrdevpd
pdyhtmvvgptasqcrvkyirrk