PDB entry 2wug

View 2wug on RCSB PDB site
Description: crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopda
Class: hydrolase
Keywords: hydrolase
Deposited on 2009-10-02, released 2009-10-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-02-02, with a file datestamp of 2010-01-29.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.192
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase bphd
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P96851
      • engineered mutation (113)
    Domains in SCOPe 2.08: d2wuga_
  • Chain 'B':
    Compound: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase bphd
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P96851
      • engineered mutation (113)
    Domains in SCOPe 2.08: d2wugb_
  • Heterogens: HPK, SCN, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wugA (A:)
mtateeltfestsrfaevdvdgplklhyheagvgndqtvvllhgggpgaaswtnfsrnia
vlarhfhvlavdqpgyghsdkraehgqfnryaamalkglfdqlglgrvplvgnalgggta
vrfaldyparagrlvlmgpgglsinlfapdptegvkrlskfsvaptrenleaflrvmvyd
knlitpelvdqrfalastpesltatramgksfagadfeagmmwrevyrlrqpvlliwgre
drvnpldgalvalktipraqlhvfgqcghwvqvekfdefnkltieflgggr

    Sequence, based on observed residues (ATOM records): (download) 
    >2wugA (A:)
ltfestsrfaevdvdgplklhyheagvgndqtvvllhgggpgaaswtnfsrniavlarhf
hvlavdqpgyghsdkraehgqfnryaamalkglfdqlglgrvplvgnalgggtavrfald
yparagrlvlmgpgglsinlfapdptegvkrlskfsvaptrenleaflrvmvydknlitp
elvdqrfalastpesltatramgksfagadfeagmmwrevyrlrqpvlliwgredrvnpl
dgalvalktipraqlhvfgqcghwvqvekfdefnkltieflgg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wugB (B:)
mtateeltfestsrfaevdvdgplklhyheagvgndqtvvllhgggpgaaswtnfsrnia
vlarhfhvlavdqpgyghsdkraehgqfnryaamalkglfdqlglgrvplvgnalgggta
vrfaldyparagrlvlmgpgglsinlfapdptegvkrlskfsvaptrenleaflrvmvyd
knlitpelvdqrfalastpesltatramgksfagadfeagmmwrevyrlrqpvlliwgre
drvnpldgalvalktipraqlhvfgqcghwvqvekfdefnkltieflgggr

    Sequence, based on observed residues (ATOM records): (download) 
    >2wugB (B:)
ltfestsrfaevdvdgplklhyheagvgndqtvvllhgggpgaaswtnfsrniavlarhf
hvlavdqpgyghsdkraehgqfnryaamalkglfdqlglgrvplvgnalgggtavrfald
yparagrlvlmgpgglsinlfapdptegvkrlskfsvaptrenleaflrvmvydknlitp
elvdqrfalastpesltatramgksfagadfeagmmwrevyrlrqpvlliwgredrvnpl
dgalvalktipraqlhvfgqcghwvqvekfdefnkltieflgg