PDB entry 2wuc
View 2wuc on RCSB PDB site
Description: Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp and Ac-KQLR-chloromethylketone
Class: hydrolase/hydrolase inhibitor
Keywords: serine protease, egf-like domain, allosteric inhibitor, kringle, antibody, hydrolase, fab complex, glycoprotein, immune system, hydrolase-hydrolase inhibitor complex
Deposited on
2009-10-01, released
2009-12-15
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-07-29, with a file datestamp of
2020-06-29.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.24
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Hepatocyte growth factor activator long chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q04756 (0-End)
- PDB 2WUC
- Chain 'B':
Compound: Hepatocyte growth factor activator short chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: fab fragment fab40.deltatrp heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: ace-kqlr-chloromethylketone inhibitor
Species: synthetic construct, synthetic [TaxId:32630]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: fab fragment fab40.deltatrp light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2wucl1, d2wucl2 - Heterogens: HOH